Beneficial effects of IL-37 after spinal cord injury in mice

Proceedings of the National Academy of Sciences of the United States of America
Marina Coll-MiróRubèn López-Vales

Abstract

IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well as acquired immunity. Whether the antiinflammatory properties of IL-37 extend to the central nervous system remains unknown, however. In the present study, we subjected mice transgenic for human IL-37 (hIL-37tg) and wild-type (WT) mice to spinal cord contusion injury and then treated them with recombinant human IL-37 (rIL-37). In the hIL-37tg mice, the expression of IL-37 was barely detectable in the uninjured cords, but was strongly induced at 24 h and 72 h after the spinal cord injury (SCI). Compared with WT mice, hIL-37tg mice exhibited increased myelin and neuronal sparing and protection against locomotor deficits, including 2.5-fold greater speed in a forced treadmill challenge. Reduced levels of cytokines (e.g., an 80% reduction in IL-6) were observed in the injured cords of hIL-37tg mice, along with lower numbers of blood-borne neutrophils, macrophages, and activated microglia. We treated WT mice with a single intraspinal injection of either full-length or processed rIL-37 after the injury and found that the IL-37-treated mice had significantly enhanced locomotor skills in an open field using the Basso Mouse Scale, as well as supported faster...Continue Reading

References

Apr 29, 2008·Journal of Neuroscience Research·David P Stirling, V Wee Yong
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin P HornJerry Silver
Aug 8, 2009·Progress in Brain Research·Jessica K Alexander, Phillip G Popovich
Oct 12, 2010·Nature Immunology·Marcel F NoldCharles A Dinarello
Aug 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rubèn López-ValesSamuel David
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eóin N McNameeJesús Rivera-Nieves
Aug 2, 2012·Nature Reviews. Drug Discovery·Charles A DinarelloJos W M van der Meer
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Armelle KlopsteinRubèn López-Vales
Nov 28, 2013·Seminars in Immunology·Charles A Dinarello, Philip Bufler
Dec 18, 2013·Immunity·Cecilia GarlandaAlberto Mantovani
Jan 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiu TengJiong Li
Feb 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ana-Maria BulauPhilip Bufler
May 13, 2014·Experimental Neurology·Phillip G Popovich
Sep 4, 2014·Nature Communications·Dov B BallakRinke Stienstra
Oct 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yuchun LuoMayumi Fujita
Oct 21, 2014·Expert Review of Clinical Immunology·Shannon Quirk, Devendra K Agrawal
Nov 7, 2014·PLoS Pathogens·Silvia MorettiLuigina Romani
Dec 6, 2014·Cold Spring Harbor Perspectives in Biology·Jerry SilverPhillip G Popovich
Feb 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Suzhao LiCharles Anthony Dinarello

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Citations

Apr 12, 2016·European Journal of Immunology·Charles A DinarelloPhilip Bufler
Oct 28, 2016·Pathology Oncology Research : POR·Vivi A DingYujiang Fang
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Qingchun ZengXianzhong Meng
Nov 16, 2017·Respiratory Research·Lina ZhangPeng Gao
Dec 17, 2017·Immunological Reviews·Charles A Dinarello
Dec 17, 2017·Immunological Reviews·Giulio Cavalli, Charles A Dinarello
Aug 4, 2018·International Journal of Molecular Sciences·Eline N KuipersMariëtte R Boon
Sep 27, 2018·Current Protocols in Immunology·Jesús Amo-AparicioRubèn López-Vales
Jun 21, 2019·Journal of Neurotrauma·Carlos A ToroChristopher P Cardozo
Mar 1, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhuo LiuCun-Jin Zhang
Apr 1, 2019·Cancer Reports·Yu Mei, Haiyan Liu
May 3, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael B Orr, John C Gensel
Oct 2, 2019·Experimental and Therapeutic Medicine·Feng ZhangQing-Min Yao
Feb 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·Suzhao LiCharles A Dinarello
Jan 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu PanXian Jiang
Jan 1, 2021·BioMed Research International·Yuanzhen ChenBin Shi
Oct 2, 2020·Brain, Behavior, and Immunity·Jesus Amo-AparicioRuben Lopez-Vales
Mar 23, 2021·Frontiers in Immunology·Steffeni MountfordPhilip Bufler
Jul 14, 2020·Seizure : the Journal of the British Epilepsy Association·Monika MocholSigrid Svalheim

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