Beneficial effects of insulin-like growth factor I on epithelial structure and function in parenterally fed rat jejunum

Gastroenterology
C A PetersonH V Carey

Abstract

The functional significance of intestinal hyperplasia stimulated by insulin-like growth factor (IGF)-I is unclear and has not been studied in a model of mucosal atrophy induced by total parenteral nutrition (TPN). The aim of this study was to determine how IGF-I affects intestinal structure and epithelial function in the absence of luminal nutrition caused by TPN. Rats were maintained with TPN with or without IGF-I (800 micrograms/day), and jejunal histology and epithelial ion transport were measured after 5 days. In a third TPN group without IGF-I, a short-term dose of IGF-I was added during in vitro flux chamber experiments. Rats given TPN with IGF-I had greater jejunal mucosal weight, greater protein and DNA content, and increased villus height and crypt depth compared with rats given TPN only. TPN increased ionic permeability and ion transport responses to secretory and absorptive agents. IGF-I in vivo reversed most of these changes; IGF-I in vitro enhanced sodium-dependent glucose absorption but had no other effects. Coinfusion of recombinant human IGF-I with TPN solution stimulates intestinal hyperplasia and attenuates transport changes induced by TPN. The latter effect seems to be primarily associated with the growth sta...Continue Reading

Citations

Feb 24, 1999·Inflammatory Bowel Diseases·P L Beck, D K Podolsky
Aug 15, 2000·Annual Review of Nutrition·R P Ferraris, H V Carey
Oct 19, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Xiaoyi SunDaniel H Teitelbaum
Jul 11, 2009·Journal of Clinical Biochemistry and Nutrition·Mariko MurakamiHiroaki Masunaga
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·John F Kuemmerle
Jan 27, 2016·Expert Opinion on Therapeutic Targets·David W LimPatricia L Brubaker
Aug 26, 2006·Developmental and Comparative Immunology·Courtney C Kurtz, Hannah V Carey
Apr 30, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Prue M Pereira-FantiniJulie E Bines
Nov 29, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Y Avery ChingTom Jaksic
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Dec 31, 2003·Molecular Psychiatry·P MonteleoneM Maj
Dec 2, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Megan D BaumlerGuy E Groblewski
Sep 14, 1999·The American Journal of Physiology·A N Alexander, H V Carey
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·K R KritschD M Ney
Dec 31, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elizabeth M DahlyDenise M Ney
Aug 13, 1999·The American Journal of Physiology·D W PowellA B West
Feb 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A N Alexander, H V Carey
May 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M B GillinghamD M Ney
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie B GillinghamDenise M Ney
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Jan 17, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hua YangDaniel H Teitelbaum
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Nov 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiaoyi SunDaniel H Teitelbaum
Jul 19, 2017·Annual Review of Nutrition·Hannah V Carey, Fariba M Assadi-Porter

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