Beneficial effects of muscone on cardiac remodeling in a mouse model of myocardial infarction

International Journal of Molecular Medicine
Xiaoyan WangTiebin Zhu

Abstract

Musk has been traditionally used in East Asia to alleviate the symptoms of angina pectoris. However, it remains unclear as to whether muscone, the main active ingredient of musk, has any beneficial effects on persistent myocardial ischemia in vivo. The aim of the present study was to investigate whether muscone can improve cardiac function and attenuate myocardial remodeling following myocardial infarction (MI) in mice. Mice were subjected to permanent ligation of the left anterior descending coronary artery to induce MI, and then randomly treated with muscone (2 mg/kg/day) or the vehicle (normal saline) for 3 weeks. Sham-operated mice were used as controls and were also administered the vehicle (normal saline). Treatment with muscone significantly improved cardiac function and exercise tolerance, as evidenced by the decrease in the left ventricular end-systolic diameter, left ventricular end-diastolic diameter, as well as an increase in the left ventricular ejection fraction, left ventricular fractional shortening and time to exhaustion during swimming. Pathological and morphological assessments indicated that treatment with muscone alleviated myocardial fibrosis, collagen deposition and improved the heart weight/body weight r...Continue Reading

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Citations

Aug 31, 2019·The Journal of Pharmacy and Pharmacology·Jie DongCong Wu
Jan 7, 2015·Journal of Asian Natural Products Research·Yu MengDa-Li Yin
Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Lucky AhmedHanyi Zhuang
Oct 23, 2019·International Journal of Molecular Medicine·Pianpian HuangLihua Liu
Apr 5, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Wei CenRalph Hoppe
Jan 13, 2018·Scientific Reports·Jianling LiuYonghua Wang
Feb 6, 2020·Journal of the Chinese Medical Association : JCMA·Chuiliang LiuYujuan Li
Jul 16, 2020·Journal of Ethnopharmacology·Jun WangLin Li
May 6, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meiyan LiuYingbin Ge

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

GraphPad Prism
Pro Plus
ImageJ
Image
SPSS

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