Beneficial effects of Nigella sativa oil on intestinal damage in necrotizing enterocolitis

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Cuneyt TaymanS Umit Sarıcı

Abstract

The aim of this study was to determine the beneficial effects of Nigella sativa oil (NSO) on rats with necrotizing enterocolitis (NEC). Thirty newborn Sprague-Dawley rats were randomly divided into three groups as NEC, NEC + NSO, and control. NEC was induced by enteral formula feeding, exposure to hypoxia-hyperoxia and cold stress. Pups in the NEC + NSO group were administered NOS at a dose of 2 ml/kg daily by intraperitoneal route from the first day until the end of the study. Proximal colon and ileum were excised for histopathologic, apoptosis (TUNEL) and biochemical evaluation, including xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malonaldehyde (MDA), and myeloperoxdase (MPO) activities. Pups in the NEC + NOS group had better clinical sickness scores and weight gain compared to the NEC group (p < 0.05). In the macroscopic assessment, histopathologic and apoptosis evaluation (TUNEL), severity of bowel damage was significantly lower in the NEC + NOS group compared to the NEC group (p < 0.05). Tissue GSH-Px and SOD levels were significantly preserved in the NEC + NSO group (p < 0.05), whereas, tissue MDA, MPO levels of the NEC + NSO group were significantly lower than those in the NEC gro...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
Aug 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Metcalfe, C Streuli
Oct 28, 1998·Environmental Health Perspectives·F J RomeroJ Romá
May 30, 2001·Journal of Ethnopharmacology·M S Al-Ghamdi
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E C Claud, W A Walker
Nov 9, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Wei HsuehF Gonzalez-Crussi
May 2, 2003·Phytotherapy Research : PTR·B H Ali, Gerald Blunden
May 31, 2003·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tahsin ColakSuha Aydin
Mar 6, 2004·Seminars in Neonatology : SN·Jane S Lee, Richard A Polin
Oct 16, 2004·Digestive Diseases and Sciences·Ismail Hameed MallickAlexander M Seifalian
Apr 28, 2005·Journal of Applied Toxicology : JAT·M A Abdel-Wahhab, S E Aly
Nov 9, 2005·International Immunopharmacology·Mohamed Labib Salem
Apr 26, 2006·Human & Experimental Toxicology·M KanterF Cagavi
May 13, 2006·Seminars in Fetal & Neonatal Medicine·Camilia R Martin, W Allan Walker
Jun 27, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jessica A ClarkBohuslav Dvorak
Jun 28, 2007·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Brigit M Carter
Dec 20, 2007·Pediatric Research·Catherine J HunterVictoria Camerini
Jan 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Omer BayrakAli Akcay
Feb 1, 2008·American Journal of Perinatology·Itzhak Brook
Mar 19, 2008·Seminars in Perinatology·Patricia W LinBarbara J Stoll
Mar 19, 2008·Seminars in Perinatology·Craig A NankervisKristina M Reber
Jun 4, 2008·Journal of Clinical Gastroenterology·Erika C Claud, W Allan Walker
Jun 13, 2008·Drugs·Alecia M Thompson, Matthew J Bizzarro
Sep 9, 2008·World Journal of Gastroenterology : WJG·Fahrettin YildizMuharrem Bitiren
Sep 20, 2008·Basic & Clinical Pharmacology & Toxicology·Uz EbruErdemli Kemal
Nov 18, 2008·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·A ZaniA Pierro
Feb 12, 2009·The Journal of Perinatal & Neonatal Nursing·Wanda Todd Bradshaw
Sep 22, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Navdeep ChehlHwyda A Arafat
Nov 20, 2009·The Journal of Surgical Research·Jill S WhitehouseDavid M Gourlay
Dec 8, 2009·Pediatric Surgery International·Renu Sharma, Joseph J Tepas
Mar 18, 2010·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Alpaslan TerziNurten Aksoy
Jul 10, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Jitendra D VaghasiyaNurudin P Jivani
Aug 10, 2010·Critical Reviews in Food Science and Nutrition·Masood Sadiq Butt, Muhammad Tauseef Sultan
Dec 15, 2010·Current Opinion in Pediatrics·Jennifer W Lee, Jonathan M Davis
Jan 21, 2011·The New England Journal of Medicine·Josef Neu, W Allan Walker
Feb 23, 2011·Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES·Deniz Necdet TihanIsmail Borucu
Feb 1, 1997·Redox Report : Communications in Free Radical Research·A J Kettle, C C Winterbourn

❮ Previous
Next ❯

Citations

May 7, 2013·Asian Pacific Journal of Tropical Biomedicine·Aftab AhmadFiroz Anwar
May 17, 2014·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Ahmet KaratasHusna Bayrakdar
Aug 26, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Mehmet Yekta OncelUgur Dilmen
Apr 1, 2014·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Oztekin CikmanMuammer Karaayvaz
Oct 5, 2019·Journal of Food Biochemistry·Sehribanu IsikEsra Cakir
Mar 30, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·HebatAlla Fathi Mohamed MousaShady Hassan Fadel
Apr 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hilal AlkisSeyithan Taysi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis