Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD: a randomized clinical study

Minerva medica
N KobyliakOleg Dynnyk

Abstract

The manipulation of gut microbiota via administration of probiotics has been proposed as a potential strategy for the treatment of non-alcoholic fatty liver disease (NAFLD). Hence, we performed a double-blind single center randomized placebo-controlled trial (RCT) to evaluate the efficacy of coadministration of probiotics with omega-3 vs. placebo in type-2 diabetic patients with NAFLD. A total of 48 patients met the criteria for inclusion. They were randomly assigned to receive "Symbiter Omega" combination of probiotic biomass supplemented with flax and wheat germ oil (250 mg of each, concentration of omega-3 fatty acids 1-5%) or placebo for 8-weeks. The primary main outcomes were the change in fatty liver index (FLI) and liver stiffness (LS) measured by Shear Wave Elastography (SWE). Secondary outcomes were the changes in transaminases level, serum lipids and cytokines levels. In probiotic-omega group, FLI significantly decreased from 83.53±2.60 to 76.26±2.96 (P<0.001) while no significant changes were observed in the placebo group (82.86±2.45 to 81.09±2.84; P=0.156). Changes of LS in both groups were insignificant. Analysis of secondary outcomes showed that the coadministration of probiotics with omega-3 lead to significant r...Continue Reading

References

Sep 25, 2001·Lancet·G MarchesiniN Melchionda
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kittichai PromratJay H Hoofnagle
May 12, 2004·Atherosclerosis·Loukianos S RallidisAikaterini S Parasi
Aug 11, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna Kotronen, Hannele Yki-Järvinen
Apr 30, 2010·The New England Journal of Medicine·Arun J SanyalUNKNOWN NASH CRN
Nov 9, 2011·Free Radical Biology & Medicine·Anabela P RoloCarlos M Palmeira
Jun 12, 2013·Journal of Hepatology·Fabio NascimbeniAmedeo Lonardo
Jul 19, 2013·Annual Review of Nutrition·E Scorletti, C D Byrne
Nov 5, 2013·World Journal of Gastroenterology : WJG·Yan-Yan MaYou-Ming Li
Jul 6, 2014·The Journal of Nutritional Biochemistry·Camila G DossiAmanda D'Espessailles
Dec 18, 2014·Reviews on Recent Clinical Trials·Nazarii Kobyliak, Ludovico Abenavoli
Dec 30, 2014·International Journal of Environmental Research and Public Health·Marina SanchezAngelo Tremblay
May 23, 2015·Journal of Diabetes and Metabolic Disorders·Galyna MykhalchyshynPetro Bodnar
Feb 13, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Xiaolin GaoChaomin Wan
Feb 24, 2016·Nutrition & Metabolism·Nazarii KobyliakPeter Kruzliak
Apr 24, 2016·Nutrition Journal·Nazarii KobyliakTetyana Falalyeyeva
Sep 22, 2016·Gastroenterology Research and Practice·Wenxia LuChuanyong Guo
Oct 1, 2016·World Journal of Gastroenterology : WJG·Giorgio Maria SaraccoAntonina Smedile
Feb 1, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gabriela S de Castro, Philip C Calder
Feb 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Fatemeh FamouriRoya Kelishadi
Apr 15, 2017·Clinical Drug Investigation·Vinicius L FerreiraRoberto Pontarolo
Jun 8, 2017·Journal of Thrombosis and Haemostasis : JTH·Wolfram Ruf, Klaus T Preissner
Jul 21, 2017·Pharmacology & Therapeutics·Donald B JumpSasmita Tripathy
Jan 10, 2018·Annals of Hepatology·Nazarii KobyliakTetyana Beregova
May 18, 2018·Diabetes Research and Clinical Practice·N KobyliakL Ostapchenko

❮ Previous
Next ❯

Citations

Oct 30, 2018·Minerva medica·Ludovico Abenavoli, Dan L Dumitrascu
May 8, 2019·Microorganisms·Haripriya GuptaKi Tae Suk
Oct 28, 2019·Minerva gastroenterologica e dietologica·Amir MariMahmud Mahamid
Apr 28, 2020·Minerva medica·Gian Paolo Caviglia
Mar 21, 2020·Panminerva Medica·Oleksandr KorotkyiLiudmila Ostapchenko
Dec 13, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Hamed Ebrahimzadeh LeylabadloHossein Bannazadeh Baghi
Oct 14, 2018·Pharmaceuticals·Ludovico AbenavoliNazarii Kobyliak
Jul 28, 2020·Critical Reviews in Food Science and Nutrition·Valentina StacchiottiFrancesco Galli
Jun 19, 2020·Journal of Diabetes and Metabolic Disorders·Nazarii KobyliakLiudmila Ostapchenko
Aug 24, 2019·International Journal of Environmental Research and Public Health·Ludovico AbenavoliAntonino De Lorenzo
Mar 21, 2019·World Journal of Diabetes·Yevheniia KyriachenkoNazarii Kobyliak
Oct 12, 2019·Minerva gastroenterologica e dietologica·Rinaldo Pellicano
Nov 23, 2019·Nutrients·Chencheng Xie, Dina Halegoua-DeMarzio
Aug 17, 2020·Nutrients·Ashley N HutchinsonRobert Jan Brummer
Oct 11, 2019·Therapeutic Advances in Gastroenterology·Yao TangHuaidong Hu
Jul 26, 2019·Minerva cardioangiologica·Irena Mladenova
Apr 15, 2020·Minerva gastroenterologica e dietologica·Ludovico AbenavoliFrancesco Luzza
Nov 2, 2019·Journal of Clinical Medicine·Sharmila Fagoonee, Rinaldo Pellicano
Nov 13, 2020·Expert Opinion on Therapeutic Targets·Mohammad BadranDavid Gozal
Dec 10, 2020·Clinical and Molecular Hepatology·Erica Jennison, Christopher D Byrne
Jul 7, 2020·Minerva gastroenterologica e dietologica·Elena MossoRinaldo Pellicano
Nov 21, 2020·Minerva endocrinologica·Ludovico AbenavoliNazarii Kobyliak
Jan 30, 2021·BMC Gastroenterology·Ammar Salehi-SahlabadiMaryam Miraghajani
Mar 16, 2021·Current Treatment Options in Gastroenterology·Marialena Mouzaki, Rohit Loomba
Mar 23, 2021·Critical Reviews in Food Science and Nutrition·Ayfer Beyaz Coşkun, Adviye Gülçin Sağdiçoğlu Celep
Mar 21, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Zhenyu ChuMiao Hou
May 27, 2021·Probiotics and Antimicrobial Proteins·Burak DoğanMustafa Calapoğlu
Aug 1, 2021·Clinical Nutrition ESPEN·Kontham Kulangara VarshaKesavan Madhavan Nampoothiri
Aug 18, 2021·Food Research International·Chao TangYingjian Lu
Aug 21, 2021·Journal of Viral Hepatitis·Bryan ChenCalvin Q Pan
Aug 18, 2020·Chemico-biological Interactions·Cai-Yu LianLin Wang
Jan 19, 2022·Minerva Gastroenterology·Tetyana FalalyeyevaNazarii Kobyliak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.