Beneficial effects of prostaglandin E1 on hemodynamic changes during liver transplantation in pigs

Transplant International : Official Journal of the European Society for Organ Transplantation
M OishiK Orita

Abstract

The vasodilative action of prostaglandin E1 (PGE1) on the systemic and pulmonary circulation was investigated in swine models of orthotopic liver transplantation. In the PGE1-treated group (n = 8), PGE1 (0.05 microgram/kg per minute) was intravenously infused from the onset of the anhepatic stage to 30 min after revascularization. During the anhepatic stage, PGE1 decreased systemic vascular resistance without a corresponding hypotension, so cardiac output was maintained at a higher level. In the control group (n = 8), pulmonary vascular resistance increased to 3 times the anhepatic value during reperfusion, accompanied by a decline in cardiac output with a 28% decrease in blood pressure. In the PGE1-treated group, on the other hand, pulmonary vascular resistance was maintained within the normal range without any associated decrease in cardiac output. The blood pressure decreased slightly by 12%. In conclusion, in this model, PGE1 increased cardiac output without hypotension during the anhepatic stage and also prevented postreperfusion pulmonary hypertension and the subsequent systemic hypotension.

References

Mar 1, 1990·Transplantation·S PostC Herfarth
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Apr 1, 1983·The American Review of Respiratory Disease·P J McDonnellG M Hutchins

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Citations

Jun 8, 2006·Transplantation Proceedings·A GattaS Faenza

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