Beneficial effects of quinaprilat on coronary vasomotor function, endothelial oxidative stress, and endothelin activation after human heart transplantation

Transplantation
Silke SteinhauffMichael Weis

Abstract

We evaluated the potential of angiotensin-converting enzyme inhibition (ACEI) to modulate resting coronary vasomotor tone and endothelial dysfunction, and to decrease vascular oxidative stress and endothelin (ET)-1 activity in human heart transplant recipients. Coronary vasomotor responses and transcardiac metabolism of glutathione, oxidized glutathione, and ET-1 were determined before and after quinaprilat infusion in 32 heart transplant recipients. Furthermore, the potential effects of ACEI on endothelial oxidative stress, ET-1 activity, and nitrosoglutathione formation were investigated using endothelial cell cultures. Epicardial diameter increased in response to quinaprilat by 6% +/- 1% (proximal segments; P<0.05) and 14% +/- 3% (distal segments; P<0.01). Coronary flow velocity increased by 2.2 +/- 0.2 (P<0.03). Coronary vasodilation to quinaprilat was negatively correlated with preexisting functional and structural coronary alterations. Quinaprilat selectively improved epicardial vasomotor response in segments with endothelial dysfunction, whereas microvascular endothelial dysfunction was unchanged. Transcardiac glutathione and big ET levels decreased after quinaprilat, whereas oxidized glutathione and ET-1 concentrations ...Continue Reading

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Citations

Nov 9, 2012·Journal of Cardiovascular Translational Research·Monica Colvin-AdamsDaniel Duprez
Jul 11, 2006·Transplantation·Thomas NickelMichael Weis
Dec 19, 2013·Current Treatment Options in Cardiovascular Medicine·Rodolfo Denadai Benatti, David O Taylor
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Mar 7, 2009·Expert Opinion on Emerging Drugs·Kiran K Khush, Hannah A Valantine
Sep 19, 2009·Expert Opinion on Drug Metabolism & Toxicology·Arne Georg KiebackThorsten Reffelmann
Mar 19, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jennifer J DevittTimothy D G Lee
Dec 16, 2006·Progress in Cardiovascular Nursing·Rebecca BoettgerSteven R Kayser
May 23, 2012·Congenital Heart Disease·Steven J Kindel, Elfriede Pahl
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Jun 10, 2017·Journal of the American College of Cardiology·William F FearonKiran Khush
Nov 7, 2007·Circulation·Andreas J FlammerRoberto Corti
Apr 23, 2008·Circulation·Daniel Schmauss, Michael Weis
May 18, 2005·Canadian Journal of Physiology and Pharmacology·Weng-Cheng ChangKuen-Yuh Wu
Mar 19, 2019·Transplantation·Andriana P Nikolova, Jon A Kobashigawa
Dec 17, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Jun-ichi SuzukiRyozo Nagai
Jun 27, 2019·Transplantation·Andriana P Nikolova, Jon A Kobashigawa

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