Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury

Neural Plasticity
Jingying ZhouXuehong Liu

Abstract

Spinal cord injury (SCI) causes a high rate of morbidity and disability. The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. Resveratrol has the potential of regulating cell growth, proliferation, metabolism, and angiogenesis through the mTOR signaling pathway. Herein, we explicate the role of resveratrol in the repair of SCI through the inhibition of the mTOR signaling pathway. The inhibition of the mTOR pathway by resveratrol has the potential of serving as a neuronal restorative mechanism following SCI.

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Citations

Apr 30, 2019·Frontiers in Molecular Neuroscience·Xizhi WangXuehong Liu
Apr 17, 2020·International Journal of Molecular Sciences·Yasmine Lund-RicardAgnès Boutet
Apr 27, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yubao LuXuegong Fan
Mar 23, 2021·Oxidative Medicine and Cellular Longevity·Anna Lucia FedulloIlaria Peluso
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jia FengLukui Chen

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