Beneficial effects of S-113m, a novel herbal prescription, on learning impairment model in mice

Biological & Pharmaceutical Bulletin
N NishiyamaH Saito

Abstract

The effects of S-113m, a novel herbal prescription consisting of Biota orientalis, Panax ginseng and Schisandra chinensis, were studied regarding learning and memory performance in the step-down and lever-press tests in normal, as well as in learning-impaired, mice. The prescription had no effect on memory registration, consolidation and retrieval processes or on motor activity in normal mice. However, a single oral administration of S-113m at doses of 250 and 500 mg/kg reduced the ethanol-induced and scopolamine-induced impairment of memory registration in the step-down test. The preparation also improved the electroconvulsive shock-induced impairment of memory consolidation in the same test. S-113m did not, however, attenuate the ethanol-induced impairment of memory retrieval. These suggest that S-113M has a preferential beneficial effect on the impairment of memory registration and memory consolidation rather than on memory retrieval in mice, through direct action on the learning and memory process.

Citations

Feb 9, 2011·Journal of the Science of Food and Agriculture·Shih-Hung YangSeu-Mei Wang
Dec 6, 2006·Journal of Asian Natural Products Research·X-Y Ren, Y Ye
Jun 19, 1998·Neuroreport·R Zhao, W F McDaniel
May 30, 2002·Biological Chemistry·Kuresh A YoudimCatherine Rice-Evans
Mar 30, 2011·PLoS Computational Biology·Dezhe Z Jin, Alexay A Kozhevnikov
Sep 2, 2008·Biological & Pharmaceutical Bulletin·Jun-ichi MorishigeKiyoshi Satouchi

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