Beneficial effects of social attachment to overcome daily stress.

Brain Research
Reji BabygirijaToku Takahashi

Abstract

Accumulation of daily life stress (chronic stress) often causes functional gastrointestinal diseases. Central oxytocin plays an important role in attenuating stress responses and regulating positive social interactions. Adult male rats were either paired or singly housed 1 week prior to the stress loading. Solid gastric emptying was measured after 7 consecutive days of chronic heterotypic stress. To study whether endogenous oxytocin is involved in restoring the delayed gastric emptying after paired housing, an oxytocin antagonist was injected intracerebroventricularly (icv) before the gastric emptying study. CRF and oxytocin mRNA expression in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) was evaluated by real time RT-PCR. In singly housed rats, chronic heterotypic stress significantly delayed gastric emptying (35.1+/-2.8%, n=6, P<or=0.01), compared to that of non-stressed rats (53.2+/-1.3%, n=6). Delayed gastric emptying observed in singly housed rats induced by chronic heterotypic stress was significantly improved by paired housing (54.8+/-3.5%, n=8, P<0.05). Central-administration of oxytocin antagonist attenuated the restored gastric emptying in paired housed rats (33.2+/-4.1%, n=6) following chronic hetero...Continue Reading

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Citations

Jan 20, 2012·Digestive Diseases and Sciences·Sazu YoshimotoToku Takahashi
Apr 3, 2012·Autonomic Neuroscience : Basic & Clinical·Reji BabygirijaToku Takahashi
Dec 20, 2011·Hormones and Behavior·Adam S Smith, Zuoxin Wang
May 7, 2011·Brain, Behavior and Evolution·Kelly G LambertCraig H Kinsley
Jan 14, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mehmet BülbülToku Takahashi
Dec 19, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mehmet BülbülGamze Tanrıöver
Nov 9, 2018·Scientific Reports·Didone FrigerioStefano Filacorda

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