Beneficial effects of statin treatment after myocardial infarction: Is progenitor cell mobilization the missing link?

International Journal of Cardiology
Dimitris TousoulisChristodoulos Stefanadis

Abstract

It is widely accepted that statin treatment improves survival in patients with myocardial infarction. Evidence also suggests that aggressive statin treatment is superior than standard dose during the post-infarction period. However, the exact mechanisms are still not well understood. Endothelial progenitor cells (EPC) play a key role in vascular homeostasis, since they contribute to the repair of damaged endothelium post-myocardial infarction, while they induce neoangiogenesis. Recent evidence suggests that statins may exert their beneficial effect in patients with recent myocardial infarction, by inducing EPC mobilization, and this may be a key mechanism by which statins improve survival in these patients. However, large scale clinical trials remain to prove that aggressive statin treatment is superior than standard dose in these patients, by inducing a more effective EPC mobilization.

References

Apr 13, 2001·JAMA : the Journal of the American Medical Association·G G SchwartzUNKNOWN Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators
Jun 8, 2002·Current Cardiology Reports·Joshua M SpinUNKNOWN American Heart Association
Jun 19, 2002·JAMA : the Journal of the American Medical Association·L Kristin NewbyUNKNOWN SYMPHONY and 2nd SYMPHONY Investigators. Sibrafiban vs Aspirin to Yield Maximun Protection From Ischemic Heart Events Post-a
Sep 17, 2003·Circulation·Scott KinlayUNKNOWN Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Study Investigators
Dec 13, 2005·International Journal of Cardiology·Dimitris TousoulisChristodoulos Stefanadis
Mar 1, 2006·Atherosclerosis. Supplements·Matthias Endres

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Citations

Sep 17, 2010·Journal of the Royal Society, Interface·Suzanne M WattGrigorios Tsaknakis
May 11, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Stefanie Dimmeler

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