Beneficial effects of synthetic KL₄ surfactant in experimental lung transplantation

The European Respiratory Journal
Alejandra SáenzCristina Casals

Abstract

The aim of this study was to investigate whether intratracheal administration of a new synthetic surfactant that includes the cationic, hydrophobic 21-residue peptide KLLLLKLLLLKLLLLKLLLLK (KL₄), might be effective in reducing ischaemia-reperfusion injury after lung transplantation. Single left lung transplantation was performed in Landrace pigs 22 h post-harvest. KL₄ surfactant at a dose of 25 mg total phospholipid·kg body weight⁻¹ (2.5 mL·kg body weight⁻¹) was instilled at 37°C to the donor left lung (n = 8) prior to explantation. Saline (2.5 mL·kg body weight⁻¹; 37°C) was instilled into the donor left lung of the untreated group (n = 6). Lung function in recipients was measured during 2 h of reperfusion. Recipient left lung bronchoalveolar lavage (BAL) provided native cytometric, inflammatory marker and surfactant data. KL(4) surfactant treatment recovered oxygen levels in the recipient blood (mean ± sd arterial oxygen tension/inspiratory oxygen fraction 424 ± 60 versus 263 ± 101 mmHg in untreated group; p=0.01) and normalised alveolar-arterial oxygen tension difference. Surfactant biophysical function was also recovered in KL₄ surfactant-treated lungs. This was associated with decreased C-reactive protein levels in BAL, and...Continue Reading

Citations

Aug 8, 2013·Therapeutic Delivery·Nashwa El-GendyPrajnaparamita Dhar
Jun 5, 2012·Biochimica Et Biophysica Acta·Cristina Casals, Olga Cañadas
Oct 17, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Barbara J Wilkey, Benjamin A Abrams
Apr 3, 2019·Frontiers in Immunology·Belén García-FojedaCristina Casals
Jul 6, 2021·Transplantation Reviews·Aadil AliLorenzo Del Sorbo

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