Beneficial effects of systemic immunoglobulin in experimental membranous nephropathy

Kidney International
M NangakuW G Couser

Abstract

To test the hypothesis that systemic administration of immunoglobulin might reduce glomerular injury in membranous nephropathy through mechanisms involving inhibition of complement activation, we studied the passive Heymann nephritis (PHN) model of membranous nephropathy in rats. The daily administration of immunoglobulin goat IgG (600 mg/kg i.p.) reduced proteinuria by 52%. Quantitative immunohistochemical analysis showed that the glomerular deposition of C3c, an indicator of ongoing complement attack, and of C5b-9 was significantly decreased in the immunoglobulin treated group, while deposition of anti-Fx1A was not affected. Electron microscopic analysis demonstrated that the extent of subepithelial immune complexes did not appreciably differ between treated and control animals. Systemic complement levels were not altered by immunoglobulin treatment. These data suggest that the reduction in proteinuria that resulted from systemic immunoglobulin administration was mediated by modifying the effect of complement induced glomerular injury. This interpretation was further supported by in vitro data that documented a significant reduction in C5b-9 induced glomerular epithelial cell lysis in the presence of both goat and rat IgG. Th...Continue Reading

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Citations

Sep 5, 2001·Kidney International·J A JeffersonW G Couser
Sep 15, 2005·American Journal of Physiology. Renal Physiology·Andrey V CybulskyDavid J Salant
Oct 28, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Seyhan ErisirSema Akman
Aug 17, 2010·Expert Opinion on Pharmacotherapy·Claudio Ponticelli, Patrizia Passerini
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Nov 30, 2004·International Journal of Experimental Pathology·Arpad Z BarabasRene Lafreniere
Jan 30, 2004·International Journal of Experimental Pathology·Arpad Z BarabasRene Lafreniere
Jul 21, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yukinari MasudaYuh Fukuda
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Dec 24, 2018·Vaccines·Arpad BarabasRene Lafreniere
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Gómez-GuerreroJ Egido

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