Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication

Journal of Agricultural and Food Chemistry
Jhih-Jia JhangGow-Chin Yen

Abstract

Gouty arthritis is characterized by the precipitation of monosodium urate (MSU) crystals in the joint. Pro-inflammatory cytokine IL-1β is a critical manifestation in response to MSU crystals attack. IL-1β secretion is dependent on the nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Abnormal activation of the NLRP inflammasome is related to cellular oxidative stress. However, recent studies have illustrated that phytochemicals with potent antioxidant activity exert inhibitory effects on NLRP3 inflammasome-mediated diseases. This review focuses on the current findings of studies on the NLRP3 inflammasome and the proposed mechanisms that MSU crystals trigger inflammation via activation of the NLRP3 inflammasome. We also summarized the potential use of phytochemicals on NLRP3 inflammasome-mediated diseases, suggesting that phytochemicals can further prevent acute gout attack.

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Citations

Sep 8, 2018·Journal of Cellular Biochemistry·Uzma SaqibMirza S Baig
Jul 3, 2019·Journal of Food Science·Dongrui ZhaoMouming Zhao
Feb 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiaojiao HanXiurong Su
Jul 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi-Jen PengChih-Chien Wang
Sep 16, 2020·International Journal of Sport Nutrition and Exercise Metabolism·David C NiemanGiuseppe Valacchi
Jul 31, 2020·Journal of Food Biochemistry·Juan Jesús Vírgen GenYessica Zamudio-Cuevas
Jul 12, 2020·International Journal of Molecular Sciences·Beatriz Castejón-VegaJosé M Alvarez-Suarez
Jun 6, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nadire Özenver, Thomas Efferth

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