Beneficial role of aminoguanidine on acute cardiomyopathy related to doxorubicin-treatment.

Molecular and Cellular Biochemistry
Y CigremisAhmet Acet

Abstract

Doxorubicin (DOX) is a broad-spectrum anthracycline antibiotic that has cardiotoxicity as a major side effect. One mechanism of this toxicity is believed to involve the reactive oxygen radical species (ROS); these agents likely account for the pathophysiology of DOX-induced cardiomyopathy. Aminoguanidine (AG) is an effective antioxidant and free radical scavenger which has long been known to protect against ROS formation. We investigated the effects of AG on DOX-induced changes in thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) content. The rats were divided into four groups:1) Control; 2) DOX group; injected intraperitoneally (i.p.) with DOX 20 mg/kg in a single dose 3) AG-treated group; injected i.p. in single dose of 20 mg/kg DOX plus 100 mg/kg AG 1 h before the DOX for 3 days, 4) AG group; injected i.p. with AG 100 mg/kg for 3 days. DOX administration to control rats increased TBARS and decreased GSH levels. AG administration before DOX injection caused significant decrease in TBARS and increase in GSH levels in the heart tissue when compared with DOX only. Morphological changes, including severe myocardial fibrosis and inflammatory cell infiltration were clearly observed in the DOX-treated hea...Continue Reading

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Citations

Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Partha MukhopadhyayPál Pacher
May 19, 2018·Journal of Cellular Biochemistry·Ferhat KalkanAhmet Acet
Oct 2, 2019·Experimental and Therapeutic Medicine·Fernando MagdalenoAna Rosa Rincón-Sánchez
Aug 20, 2009·Cardiology in Review·Kuldeep Maradia, Maya Guglin
Aug 8, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Hakan ParlakpinarCemil Colak
Mar 23, 2010·Toxicologic Pathology·Jeffrey A KramerAlan G E Wilson
Oct 26, 2013·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·O M DisliH Parlakpinar
Feb 21, 2013·Human & Experimental Toxicology·V AricaA Nacar
Jun 8, 2013·The International Journal of Cardiovascular Imaging·Mohamed AissiouDaniel Curnier
Oct 3, 2009·Toxicology and Applied Pharmacology·Beshay N M ZordokyAyman O S El-Kadi
Jun 5, 2021·Nutrition and Cancer·Mahboobeh Ghasemzadeh RahbardarHossein Hosseinzadeh

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