Beneficial Role of Some Natural Products to Attenuate the Diabetic Cardiomyopathy Through Nrf2 Pathway in Cell Culture and Animal Models

Cardiovascular Toxicology
V V Sathibabu UddandraoGanapathy Saravanan

Abstract

Diabetic cardiomyopathy, as one of the main cardiac complications in diabetic patients, is identified to connect with oxidative stress that is due to interruption in balance between reactive oxygen species or/and reactive nitrogen species generation and their clearance by antioxidant protection systems. Transcription factor the nuclear factor erythroid 2-related factor 2 (Nrf2) plays a significant role in maintaining the oxidative homeostasis by regulating multiple downstream antioxidants. The Nrf2 plays a significant role in ARE-mediated basal and inducible expression of more than 200 genes that can be grouped into numerous categories as well as antioxidant genes and phase II detoxifying enzymes. On the other hand, activation of Nrf2 by natural and synthetic therapeutics or antioxidants has been revealed effective for the prevention and treatment of toxicities and diseases connected with oxidative stress. Hence, recently focus has been shifted toward plants and plant-based medicines in curing such chronic diseases, as they are supposed to be less toxic. In this review, we focused on the role of some natural products on diabetic cardiomyopathy through Nrf2 pathway.

References

Mar 10, 2001·The Journal of Nutrition·H AmagaseY Itakura
Sep 6, 2002·Cardiovascular Toxicology·L Cai, Y J Kang
Oct 23, 2004·Drug Metabolism and Pharmacokinetics·Hiroyuki TsudaMalcolm A Moore
Nov 3, 2004·Trends in Molecular Medicine·Hozumi Motohashi, Masayuki Yamamoto
Jun 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jong-Min LeeJeffrey A Johnson
Feb 27, 2007·Journal of Molecular and Cellular Cardiology·Milton HamblinMichael F Hill
Jun 27, 2007·Circulation·Sihem Boudina, E Dale Abel
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Dipak K Das
Mar 8, 2008·Cellular and Molecular Life Sciences : CMLS·H HatcherS V Torti
May 20, 2008·Mutation Research·Joydeb Kumar Kundu, Young-Joon Surh
Jun 13, 2008·The Journal of Nutritional Biochemistry·Chi-Tai YehGow-Chin Yen
Jul 18, 2009·Circulation Research·John W CalvertDavid J Lefer
Aug 12, 2009·Free Radical Biology & Medicine·James W KasparAnil K Jaiswal
Sep 25, 2010·Cell Death and Differentiation·S K Niture, A K Jaiswal
Mar 3, 2011·Archives of Toxicology·Liam Baird, Albena T Dinkova-Kostova
Mar 13, 2012·Cell Metabolism·Houman AshrafianHugh Watkins
May 1, 2012·Journal of Diabetes and Its Complications·Ganapathy Saravanan, Ponnusamy Ponmurugan
Jun 30, 2012·Cancer Letters·Hui TianJunNian Zheng
Dec 29, 2012·Recent Patents on Food, Nutrition & Agriculture·Raju Padiya, Sanjay K Banerjee
Jan 11, 2013·BioFactors·Adeeb Shehzad, Young Sup Lee
Apr 6, 2013·Exercise and Sport Sciences Reviews·Danielle J ReulandKaryn L Hamilton
Jun 12, 2013·Canadian Journal of Physiology and Pharmacology·Tarak Nath KhatuaSanjay K Banerjee
Apr 25, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Carolyn Sp Lam
Jul 18, 2015·World Journal of Diabetes·Mark T WaddinghamJames T Pearson
Dec 18, 2015·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee
Jul 5, 2016·Canadian Journal of Diabetes·Parim Brahma NaiduGanapathy Saravanan

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Citations

Mar 20, 2018·Archives of Physiology and Biochemistry·Kalaivani AVadivukkarasi Sasikumar
Feb 12, 2019·Archives of Physiology and Biochemistry·V V Sathibabu UddandraoSaravanan Ganapathy
Jan 21, 2021·Archives of Physiology and Biochemistry·Jansy Isabella Rani AS Vadivukkarasi
Feb 8, 2020·Cardiovascular & Hematological Agents in Medicinal Chemistry·V V Sathibabu UddandraoSaravanan Ganapathy

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Methods Mentioned

BETA
glycosylation
nuclear translocation
acetylation
transgenic

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