Benefit of consolidative radiation therapy for primary bone diffuse large B-cell lymphoma

International Journal of Radiation Oncology, Biology, Physics
Randa TaoBouthaina S Dabaja

Abstract

Outcomes for patients with diffuse large B-cell lymphoma (DLBCL) differ according to the site of presentation. With effective chemotherapy, the need for consolidative radiation therapy (RT) is controversial. We investigated the influence of primary bone presentation and receipt of consolidative RT on progression-free survival (PFS) and overall survival (OS) in patients with DLBCL. We identified 102 patients with primary bone DLBCL treated consecutively from 1988 through 2013 and extracted clinical, pathologic, and treatment characteristics from the medical records. Survival outcomes were calculated by the Kaplan-Meier method, with factors affecting survival determined by log-rank tests. Univariate and multivariate analyses were done with a Cox regression model. The median age was 55 years (range, 16-87 years). The most common site of presentation was in the long bones. Sixty-five patients (63%) received R-CHOP-based chemotherapy, and 74 (72%) received rituximab. RT was given to 67 patients (66%), 47 with stage I to II and 20 with stage III to IV disease. The median RT dose was 44 Gy (range, 24.5-50 Gy). At a median follow-up time of 82 months, the 5-year PFS and OS rates were 80% and 82%, respectively. Receipt of RT was associa...Continue Reading

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Citations

Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Chelsea C Pinnix
Sep 2, 2017·Tumori·Ombretta AnnibaliGiuseppe Avvisati
Jan 4, 2018·JBJS Reviews·Robert J SteffnerNicholas C Danford
Jun 23, 2018·Current Treatment Options in Oncology·Thomas A Ollila, Adam J Olszewski
Jan 2, 2019·Case Reports in Pathology·Shachar KenanSamuel Kenan
Oct 1, 2020·Therapeutic Advances in Hematology·Chen-Xin LiuYan-Hua Zheng
Sep 15, 2018·Clinical Case Reports·Turker YucesoyKemal Deniz
Jun 5, 2020·The Cancer Journal·Brandon S Imber, Joachim Yahalom
Mar 2, 2021·SAGE Open Medical Case Reports·Emam M KhederHussain Al Omar
Mar 17, 2021·Bulletin du cancer·Illias TaziFatima Zahara Lahlimi

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