Benefit of double-reading cytology smears as a triage strategy among high-risk human papillomavirus-positive women in Mexico.

Cancer Cytopathology
Paula Ramírez-PalaciosFRIDA Study Investigators

Abstract

The goal of this study was to determine whether the detection of histologically confirmed cases of cervical high-grade squamous intraepithelial lesions or worse (HSIL+) can be increased by having each liquid-based cytology (LBC) slide read by 2 cytotechnologists as part of routine screening. Over 36,212 women aged 30 to 64 years participated in the Forwarding Research for Improved Detection and Access for Cervical Cancer Screening and Triage (FRIDA) Study in Mexico between 2013 and 2016. For each participant, 2 cervical samples were collected at the same clinic visit, one to test for high-risk human papillomavirus (hrHPV) and the other for LBC, which was used to triage those with a hrHPV positive result. LBC slides were evaluated by 7 cytotechnologists, with each slide read independently by 2 blinded cytotechnologists. All women with atypical cells of undetermined significance or a worse result were referred to colposcopy for further evaluation and diagnosis. Three pathologists evaluated the biopsy specimens to confirm the final HSIL+ diagnosis. The HSIL+ detection rates for the single versus double reading were estimated and compared. A total of 3,914 women with a positive hrHPV result were triaged with LBC. The first and seco...Continue Reading

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Citations

Dec 1, 2020·International Journal of Cancer. Journal International Du Cancer·Leticia Torres-IbarraJorge Salmerón

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