Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study.

Journal of Neurointerventional Surgery
Adam de HavenonARISE II investigators

Abstract

The benefit of endovascular thrombectomy for acute ischemic stroke with M2 segment middle cerebral artery occlusion remains controversial, with uncertainty and paucity of data specific to this population. To compare outcomes between M1 and M2 occlusions in the Analysis of Revascularization in Ischemic Stroke with EmboTrap (ARISE II) trial. We performed a prespecified analysis of the ARISE II trial with the primary outcome of 90-day modified Rankin Scale score of 0-2, which we termed good outcome. Secondary outcomes included reperfusion rates and major adverse events. The primary predictor was M2 occlusion, which we compared with M1 occlusion. We included 183 patients, of whom 126 (69%) had M1 occlusion and 57 (31%) had M2 occlusion. There was no difference in the reperfusion rates or adverse events between M2 and M1 occlusions. The rate of good outcome was not different in M2 versus M1 occlusions (70.2% vs 69.7%, p=0.946). In a logistic regression model adjusted for age, sex, and baseline National Institutes of Health Stroke Scale score, M2 occlusions did not have a significantly different odds of good outcome compared with M1 occlusions (OR 0.94, 95% CI 0.47 to 1.88, p=0.87). In ARISE II, M2 occlusions achieved a 70.2% rate of...Continue Reading

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Citations

May 29, 2021·Journal of Neurointerventional Surgery·Patricio MuszynskiUNKNOWN ETIS Registry Investigators
Jul 23, 2021·Stroke; a Journal of Cerebral Circulation·Erica Camargo, Ashutosh P Jadhav
Jul 28, 2021·Stroke; a Journal of Cerebral Circulation·Mouhammad A JumaaSantiago Ortega-Gutierrez

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