PMID: 8582783Sep 1, 1995Paper

Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS

International Journal of Immunopharmacology
E MocchegianiN Fabris

Abstract

Zinc is perhaps the most important trace element for immune function. Congenital or acquired zinc deficiencies are associated with immune abnormalities and increased susceptibility to infectious diseases. AIDS subjects suffer from reduced zinc bioavailability, more severe in stage IV than in stage III. Such zinc deficiency causes, among other effects, a profound reduction in the biological activity of one of the thymic hormones, thymulin (zinc-facteur-timique-serique, ZnFTS). With these premises, zinc sulphate was administered orally at a daily dose of 200 mg for 30 days to AZT-treated stage III subjects with generalized lymphadenopathy (17 subjects) and stage IV subgroup C1 (12 subjects) AIDS patients. 18 stage III subjects with generalized lymphoadenopathy and 10 stage IV subgroup C1 subjects treated only with AZT served as controls. Zinc sulphate supplementation of stage III and in stage IV C1 patients was followed by an increase or a stabilization in the body weight and an increase of the number of CD4+ cells and the plasma level of active zinc-bound thymulin. The frequency of opportunistic infectious episodes in the 24 months following entry into the study was reduced after zinc supplementation in stage IV C1 subjects (11 ...Continue Reading

References

Apr 15, 1978·British Medical Journal
Jul 10, 1992·Science·L MeyaardF Miedema
Aug 1, 1992·Current Opinion in Immunology·M B Feinberg, W C Greene
Dec 26, 1992·Annals of the New York Academy of Sciences·G GrassoN Fabris
May 1, 1989·The Journal of Pediatrics·G LockitchG Quigley
Jul 1, 1989·Diabetes·E MocchegianiN Fabris
Oct 1, 1988·The Journal of Clinical Investigation·A S PrasadM Dardenne
Jan 1, 1986·American Journal of Hematology·O F BallesterA S Prasad
Jan 1, 1985·Journal of the American College of Nutrition·C J McClain
Nov 18, 1972·Lancet·J F BachH Le Brigand
Jan 1, 1984·Annals of the New York Academy of Sciences·J W Gold, D Armstrong
Jan 1, 1981·European Neurology·S C RastogiT Fog
Feb 14, 1984·Biochimica Et Biophysica Acta·L N GastinelJ F Bach
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M DardenneJ F Bach
Jun 1, 1995·Clinical Immunology and Immunopathology·E MocchegianiN Fabris
Oct 8, 1994·Lancet·D M Chaput de Saintonge, A Herxheimer
May 31, 1994·Annals of the New York Academy of Sciences·N Fabris
Jan 9, 1993·Lancet·W LuJ M Andrieu
Jan 1, 1993·AIDS Care·K PughJ Catalan
Sep 1, 1995·International Journal of Immunopharmacology·M ProvincialiN Fabris

❮ Previous
Next ❯

Citations

Apr 1, 1995·Aging : Clinical and Experimental Research·N Fabris, E Mocchegiani
Sep 28, 2005·Archives of Toxicology·M StefanidouC Spiliopoulou
Sep 1, 1995·International Journal of Immunopharmacology·J W Hadden
Jul 18, 1997·International Journal of Pediatric Otorhinolaryngology·M OnerciO Oğretmenoğlu
Jul 17, 1999·International Journal of Immunopharmacology·E MocchegianiG Scalise
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Mustafa Vecdi ErtekinOrhan Sezen
Aug 6, 1999·The British Journal of Nutrition·R D Semba, A M Tang
Jan 11, 2000·The Proceedings of the Nutrition Society·L Rink, P Gabriel
Jun 1, 2000·Nutrition Research Reviews·P C Calder, A A Jackson
Aug 18, 2001·The British Journal of Nutrition·P Bhaskaram
Mar 26, 2003·The British Journal of Nutrition·M E VisserG D Hussey
May 12, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marianna K BaumAdriana Campa
Dec 15, 2010·AIDS Research and Human Retroviruses·Carlin RafieMarianna K Baum
Jan 1, 1997·International Journal of Clinical & Laboratory Research·S Della BellaR Scorza
Jul 16, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Martina Maywald, Lothar Rink
Sep 8, 2011·Tropical Medicine & International Health : TM & IH·Linan Zeng, Lingli Zhang
May 31, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Song MaoSongming Huang
Jun 21, 2017·Nutrients·Nour Zahi Gammoh, Lothar Rink
Jun 14, 2018·DNA and Cell Biology·Nidhi KaushikMilan Surjit
Aug 28, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Ananda S Prasad
Jun 30, 2014·The Cochrane Database of Systematic Reviews·Anjana Gulani, Harshpal S Sachdev
Jun 7, 2013·Bioscience Reports·Sian L StaffordMatthew J Sweet
Jun 19, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·H LaiM K Baum
May 10, 2000·The Journal of Nutrition·M K BaumA Campa
Jul 16, 2019·Advances in Nutrition·Scott A ReadGolo Ahlenstiel
Apr 25, 2020·Viruses·Nabab KhanJonathan D Geiger
May 6, 2003·The Journal of Nutrition·Klaus-Helge Ibs, Lothar Rink
May 10, 2000·The Journal of Nutrition·L Rink, H Kirchner
Apr 3, 2020·Biological Trace Element Research·Karen Cilliers, Christo J F Muller
Feb 13, 2010·Journal of the American College of Nutrition·Ananda S Prasad
May 10, 2000·The Journal of Nutrition·E Mocchegiani, M Muzzioli
Feb 10, 2021·Journal of Animal Physiology and Animal Nutrition·Partha Sarathi SwainSellapan Selvaraju
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Alireza JafariElnaz Daneshzad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Annals of the New York Academy of Sciences
E MocchegianiN Fabris
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
J F ZazzoP M Girard
Journal of Acquired Immune Deficiency Syndromes : JAIDS
César CárcamoKing K Holmes
© 2021 Meta ULC. All rights reserved