Benefit of radiotherapy for 90 patients with resected intrahepatic cholangiocarcinoma and concurrent lymph node metastases.

Journal of Cancer Research and Clinical Oncology
Wei JiangYun-Shan Tan

Abstract

To evaluate the role of radiotherapy for patients with resected intrahepatic cholangiocarcinoma with concurrent macroscopic abdominal lymph node metastases. We identified 90 patients with resected intrahepatic cholangiocarcinoma and concurrent regional lymph node metastases treated between 1999 and 2008, thereinto 24 patients received local limited external beam radiotherapy (classified as the radiotherapy group) with a median total dose of 50 Gy (range 34-60 Gy) in fractions of 2 Gy five times a week. The remaining 66 patients did not receive external beam radiotherapy (classified as the non-radiotherapy group). We studied survival and tumor response to radiotherapy, demonstrated by symptoms and results of imaging, by Kaplan-Meier method and Cox analysis. After radiotherapy, lymph nodes showed partial response in nine patients (37.5%) and complete response in nine patients (37.5%). Median survival was 19.1 months in the radiotherapy group and 9.5 months in the non-radiotherapy group (P = 0.011). Multivariate analysis showed that increasing age, multiple intrahepatic primary tumors, higher level of CA19-9, and non-radiotherapy group were related to a poorer prognosis. The most common cause of death was intrahepatic recurrence, ...Continue Reading

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Citations

Dec 31, 2010·Frontiers of Medicine in China·Shang-Long LiuQi-Chang Zheng
Dec 5, 2013·BMC Cancer·Laurence Moureau-ZabottoFrancois Bertucci
Mar 29, 2014·Practical Radiation Oncology·Prajnan DasChristopher H Crane
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Dec 18, 2020·Seminars in Interventional Radiology·Pouya Entezari, Ahsun Riaz
Jan 1, 2021·Frontiers in Oncology·Eleni GkikaThomas B Brunner
Feb 4, 2021·Current Problems in Surgery·T Peter KinghamMichael I D'Angelica
Jun 3, 2021·Journal of Clinical Medicine·Guergana PanayotovaKeri E Lunsford

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