Benefits and limitations of drug studies in temperament research: biochemical responses as indicators of temperament

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Petra Netter

Abstract

This paper presents a discussion of principles and problems of neurotransmitter challenge tests using examples of experiments, most of which were performed in the author's laboratory. Drugs targeting synthesis, release, receptors or reuptake of dopamine, serotonin and noradrenergic transmitter (TM) systems were used for characterizing or discriminating certain temperament or personality traits and their sub-factors. Any personality or temperament trait is characterized by multiple TM responses, thus constellations of hormone responses to drugs acting on different TM systems or on different sources of TM activity were investigated within individuals in crossover designs. The major conclusions are: (i) intra-individual patterns of hormone responses to different TM-related drugs, or to agonists and antagonists, can help to discriminate subtypes of temperament dimensions, and (ii) the latency and shape of response curves may help specify processes of biological responses related to psychological dimensions and reveal common TM sensitivities in clusters of traits. TM sensitivity, defined by hormone responses, does not always correspond to accompanying behavioural indicators, but may provide more specific information on underlying me...Continue Reading

References

Aug 1, 1976·Journal of Abnormal Psychology·L J ChapmanM L Raulin
Jan 1, 1992·Molecular Aspects of Medicine·A C Power, P J Cowen
Dec 1, 1991·Psychological Reports·C R CloningerD M Svrakic
Dec 1, 1990·The International Journal of Neuroscience·T Rammsayer, P Netter
Apr 1, 1989·Alcoholism, Clinical and Experimental Research·W H Vogel, P Netter
Jan 1, 1968·Psychosomatic Medicine·M FrankenhaeuserP Pátkai
Feb 1, 1994·Journal of Computer-aided Molecular Design·D J Abraham, G E Kellogg
Jul 1, 1993·Pharmacology, Biochemistry, and Behavior·N R SwerdlowR L Hauger
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Nov 1, 1995·Journal of Clinical Psychology·J H PattonE S Barratt
Jan 1, 1996·Neuropsychobiology·P NetterI S Roed
Apr 3, 1998·Pharmacopsychiatry·J HennigP Netter
Aug 7, 1998·Biological Psychiatry·I Lucki
Mar 10, 1999·Pharmacopsychiatry·P NetterS Rohrmann
Feb 13, 2001·Psychoneuroendocrinology·W PitchotM Ansseau
Jan 12, 2002·Current Opinion in Pharmacology·Johannes M H M Reul, Florian Holsboer
Oct 9, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Martin ReuterJuergen Hennig
Oct 9, 2002·International Clinical Psychopharmacology·David J Nutt
May 1, 1965·The American Journal of Psychiatry·G HENINGERG L KLERMAN
Jan 31, 2006·Human Psychopharmacology·P Netter
May 16, 2009·Current Pharmaceutical Design·Francisco López-Muñoz, Cecilio Alamo
Sep 15, 2009·Behavioural Brain Research·Yvonne KuepperJuergen Hennig
Mar 13, 2016·Neuroscience and Biobehavioral Reviews·Irina Trofimova, Trevor W Robbins
Jun 1, 1994·Nursing Standard·J Rogers

❮ Previous
Next ❯

Citations

Nov 18, 2018·Acta Psychiatrica Scandinavica·Kevin C RunionsFlorian D Zepf
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I TrofimovaJ Uher
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jana UherLouis A Schmidt
Aug 9, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·David A Lovejoy, David W Hogg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Vladimir Rusalov
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Hannah SallisMarcus R Munafò
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Irina TrofimovaJana Uher
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Françoise Dellu-HagedornPhilippe De Deurwaerdère
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Lars FardeSimon Cervenka
© 2022 Meta ULC. All rights reserved