Benefits and pitfalls of pooling datasets from comparable observational studies: combining US and Dutch nursing home studies

Palliative Medicine
Jenny T van der SteenRalph B D'Agostino

Abstract

Different research groups sometimes carry out comparable studies. Combining the data can make it possible to address additional research questions, particularly for small observational studies such as those frequently seen in palliative care research. We present a systematic approach to pool individual subject data from observational studies that addresses differences in research design, illustrating the approach with two prospective observational studies on treatment and outcomes of lower respiratory tract infection in US and Dutch nursing home residents. Benefits of pooling individual subject data include enhanced statistical power, the ability to compare outcomes and validate models across sites or settings, and opportunities to develop new measures. In our pooled dataset, we were able to evaluate treatments and end-of-life decisions for comparable patients across settings, which suggested opportunities to improve care. In addition, greater variation in participants and treatments in the combined dataset allowed for subgroup analyses and interaction hypotheses, but required more complex analytic methods. Pitfalls included the large amount of time required for equating study procedures and variables and the need for additiona...Continue Reading

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Citations

Feb 6, 2009·International Psychogeriatrics·Jenny T van der SteenLadislav Volicer
Nov 17, 2012·Journal of Palliative Medicine·Jenny T van der SteenBregje D Onwuteaka-Philipsen
Jan 11, 2013·Environmental Health : a Global Access Science Source·Rebecca B McNeilDawn T Provenzale
Apr 26, 2011·Journal of the American Medical Directors Association·Kristina L SzafaraJenny T van der Steen
Mar 7, 2015·The Annals of Thoracic Surgery·Chao DongWen Ouyang
Apr 16, 2015·PloS One·Xhyljeta LutaKerri M Clough-Gorr
Feb 14, 2018·International Journal of Epidemiology·Catherine R LeskoBryan Lau
Oct 13, 2019·BMJ Supportive & Palliative Care·Melissa ArneilAlexandra McCarthy
May 2, 2019·Frontiers in Psychology·Neil DagnallAndrew Parker
Sep 14, 2018·Frontiers in Psychology·Kenneth DrinkwaterAndrew Parker
Dec 10, 2008·Scandinavian Journal of Infectious Diseases·Jenny T Van Der SteenBregje D Onwuteaka-Philipsen
Oct 24, 2020·The Australian and New Zealand Journal of Psychiatry·Robson ZazulaOlivia M Dean
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May 2, 2013·Alzheimer Disease and Associated Disorders·Jenny T van der SteenBregje D Onwuteaka-Philipsen

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