Benefits in radical mastectomy protocol: a randomized trial evaluating the use of regional anesthesia

Scientific Reports
Marcio MatsumotoRaquel C R Martinez

Abstract

Surgery is the first-line treatment for early, localized, or operable breast cancer. Regional anesthesia during mastectomy may offer the prevention of postoperative pain. One potential protocol is the combination of serratus anterior plane block (SAM block) with pectoral nerve block I (PECS I), but the results and potential benefits are limited. Our study compared general anesthesia with or without SAM block + PECS I during radical mastectomy with axillary node dissection and breast reconstruction using evaluations of pain, opioid consumption, side effects and serum levels of interleukin (IL)-1beta, IL-6 and IL-10. This is a prospective, randomized controlled trial. Fifty patients were randomized to general anesthesia only or general anesthesia associated with SAM block + PECS I (25 per group). The association of SAM block + PECS I with general anesthesia reduced intraoperative fentanyl consumption, morphine use and visual analog pain scale scores in the post-anesthetic care unit (PACU) and at 24 h after surgery. In addition, the anesthetic protocol decreased side effects and sedation 24 h after surgery compared to patients who underwent general anesthesia only. IL-6 levels increased after the surgery compared to baseline level...Continue Reading

References

Jan 1, 1997·British Journal of Cancer·E VenetsanakosJ M Skinner
Jan 13, 2006·The Breast : Official Journal of the European Society of Mastology·Leticia Llanes-FernándezCristina Rodríguez-Padilla
Sep 9, 2006·Current Opinion in Anaesthesiology·J Eric Greensmith, W Bosseau Murray
Sep 29, 2006·Anesthesiology·Aristomenis K ExadaktylosDaniel I Sessler
Jun 16, 2010·Current Drug Targets·Jodi E Goldberg, Kathryn L Schwertfeger
Oct 27, 2010·Regional Anesthesia and Pain Medicine·Catherine A DeeganDonal J Buggy
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·Mingli LvZhongwei Lv
Aug 9, 2011·Current Opinion in Anaesthesiology·James R Hebl, Adam D Niesen
Nov 8, 2011·Breast Cancer Research and Treatment· HamidullahRituraj Konwar
Sep 4, 2012·Revista española de anestesiología y reanimación·R BlancoT Parras Maldonado
Oct 23, 2013·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Tania Cursino de Menezes CouceiroMelania M R Amorim
Aug 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying LiWen Si
Sep 6, 2014·European Journal of Anaesthesiology·Philipp LirkMarkus W Hollmann
Nov 8, 2014·Regional Anesthesia and Pain Medicine·Ghada Mohammad Nabih Bashandy, Dina Nabil Abbas
Dec 7, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jiang WuDaniel I Sessler
Feb 19, 2015·British Journal of Anaesthesia·J KesslerM W Hollmann
Feb 28, 2015·Breast Cancer Research and Treatment·Kaoru FujisakiMasaru Miyazaki
Apr 30, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y T CheungA Chan
Jun 1, 2015·Revista española de anestesiología y reanimación·B M Lee, J P Cata
Dec 30, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neil M IyengarAndrew J Dannenberg
Jan 13, 2016·Anesthesia and Analgesia·Meredith M PacePeter Stefanovich
Jan 19, 2016·Revista española de anestesiología y reanimación·P DiéguezM Fajardo

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Citations

May 10, 2020·Anesthesia and Analgesia·Robert B ManikerDe Q Tran
Dec 4, 2019·Regional Anesthesia and Pain Medicine·Mark C Kendall, Gildasio S De Oliveira
Nov 12, 2020·Regional Anesthesia and Pain Medicine·Alexander BeletskyRodney Allanigue Gabriel
Jan 12, 2021·Plastic and Reconstructive Surgery. Global Open·Hassan ElHawaryJeffrey E Janis
Dec 10, 2020·A&A Practice·Filipa P Pedrosa, Hugo Cravo

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Methods Mentioned

BETA
biopsy
dissection
hormone replacement therapy
sedation
enzyme-linked immunosorbent assay
ELISA

Clinical Trials Mentioned

NCT02647385

Software Mentioned

REDCap Electronic Capture
CONSORT
Elisa

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