Benefits of adversity?! How life history affects the behavioral profile of mice varying in serotonin transporter genotype

Frontiers in Behavioral Neuroscience
Carina BoddenNorbert Sachser

Abstract

Behavioral profiles are influenced by both positive and negative experiences as well as the genetic disposition. Traditionally, accumulating adversity over lifetime is considered to predict increased anxiety-like behavior ("allostatic load"). The alternative "mismatch hypothesis" suggests increased levels of anxiety if the early environment differs from the later-life environment. Thus, there is a need for a whole-life history approach to gain a deeper understanding of how behavioral profiles are shaped. The aim of this study was to elucidate the effects of life history on the behavioral profile of mice varying in serotonin transporter (5-HTT) genotype, an established mouse model of increased anxiety-like behavior. For this purpose, mice grew up under either adverse or beneficial conditions during early phases of life. In adulthood, they were further subdivided so as to face a situation that either matched or mismatched the condition experienced so far, resulting in four different life histories. Subsequently, mice were tested for their anxiety-like and exploratory behavior. The main results were: (1) Life history profoundly modulated the behavioral profile. Surprisingly, mice that experienced early beneficial and later escapab...Continue Reading

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Citations

Nov 17, 2015·Social Cognitive and Affective Neuroscience·Manuel KuhnTina B Lonsdorf
Oct 21, 2016·Frontiers in Behavioral Neuroscience·Jasmin RemmesThomas Seidenbecher
May 10, 2018·Frontiers in Behavioral Neuroscience·Niklas KästnerNorbert Sachser
May 12, 2017·Frontiers in Cellular Neuroscience·Danielle J HouwingJocelien D A Olivier
Aug 3, 2021·Current Opinion in Behavioral Sciences·Norbert SachserSylvia Kaiser

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Methods Mentioned

BETA
environmental challenge
PCR
electrophoresis
genotyping
light microscopy

Software Mentioned

ANY
SPSS Statistics
SigmaPlot
maze
Systat

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