Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mirela Donato GianetiPatrícia Maria Berardo Gonçalves Maia Campos

Abstract

Chemically stable ester derivatives of vitamins A, C and E have become a focus of interest for their role in the satisfactory results in skin aging treatments. Accordingly, the aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl acetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer was used to determine rheological behavior of formulations containing the vitamins. Chemical stability was determined by HPLC on a Shimadzu system with UV detection. Results showed that formulations had pseudoplastic behavior and that vitamins did not alter their apparent viscosity and thixotropy. In the chemical stability studies, first-order reaction equations were used for determinations of the shelf-life of vitamins derivatives considering a remaining concentration of 85%. Combined vitamins in a single formulation had a slightly lower degradation rate as compared to different preparations containing only one of the vitamins. Considering that many cosmetic formulations contain vitamin combinations it is suggested that the present study may contribute to the development of more stable formul...Continue Reading

References

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Citations

Jul 11, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vitor C Seixas, Osvaldo A Serra
Nov 13, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mirela D Gianeti, Patrícia M B G Maia Campos
Sep 15, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Patrícia M B G Maia CamposLorena R Gaspar
Oct 3, 2015·Carbohydrate Polymers·Renata Moschini DaudtIrene Clemes Külkamp-Guerreiro
Sep 24, 2013·TheScientificWorldJournal·Tariq Mahmood, Naveed Akhtar
May 11, 2016·The Journal of Dermatological Treatment·P M B G Maia CamposB Closs-Gonthier
May 24, 2017·Pharmaceutical Development and Technology·Renata Moschini DaudtIrene Clemes Külkamp Guerreiro
Jul 23, 2020·International Journal of Cosmetic Science·Francine C S César, Patrícia M B G Maia Campos
Aug 20, 2020·Journal of Cosmetic Dermatology·Žane Temova RakušaRobert Roškar
Jan 5, 2020·AAPS PharmSciTech·V T P FerreiraP M B G Maia Campos
Nov 19, 2020·Journal of Cosmetic Dermatology·Žane Temova RakušaRobert Roškar
Nov 5, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Amanda Costa CaritáGislaine Ricci Leonardi
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca Maria JuncanFelicia Loghin

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