Benefits of umbilical cord milking versus delayed cord clamping on neonatal outcomes in preterm infants: A systematic review and meta-analysis

PloS One
Nobuhiko NaganoErika Ota

Abstract

Optimum timing of umbilical cord clamping has not been established in preterm infants. We compared the short- and long-term effects of umbilical cord milking (UCM) versus delayed cord clamping (DCC) on infants born at less than 37 weeks of gestation. A systematic review and meta-analysis was conducted according to the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" statement. We searched CINAHL, CENTRAL, EMBASE, MEDLINE, PubMed and ClinicalTrials.gov for relevant randomized controlled trials (RCTs). We included individual and clustered RCTs comparing UCM to DCC for infants born before 37 weeks of gestation. Four reviewers independently assessed trial quality and eligibility for inclusion. Two trials (255 preterm infants, 23 0/7 to 32 6/7 weeks of gestation) were included in the analysis. UCM was associated with fewer intraventricular hemorrhages (IVHs) (two trials, 255 infants; relative risk [RR] 0.45, 95% confidence interval [CI] 0.20 to 0.98, low quality of evidence) and UCM was an increased proportion of infants with a Bayley score at 2 years of age (two trials, 174 infants; Cognitive: RR 1.14, 95% CI 1.03 to 1.26, Language: RR 1.24, 95% CI 1.03 to 1.49, low quality of evidence) compared to DCC. UCM wasn...Continue Reading

References

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Citations

Sep 26, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Kazumasa FuwaFumihiko Namba
Apr 22, 2020·Pediatric Research·Joshuan J BarbozaAdrian V Hernandez
Jul 14, 2020·Frontiers in Pediatrics·Liam MahoneyDavid Odd
Aug 13, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Walid El-NaggarDavid Simpson
Mar 16, 2019·Frontiers in Pediatrics·Michael P Meyer, Elizabeth Nevill
Apr 7, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Jogender Kumar, Arushi Yadav
Aug 1, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Neha KumbhatUNKNOWN undefined
Apr 15, 2020·Journal of Clinical Medicine·Inmaculada Ortiz-EsquinasAntonio Hernández-Martínez
Mar 11, 2020·Archives of Disease in Childhood. Fetal and Neonatal Edition·Haribalakrishna BalasubramanianNandkishor Kabra
Jul 1, 2020·American Journal of Obstetrics and Gynecology·Luis Sanchez-RamosAndrew M Kaunitz
Oct 28, 2019·Seminars in Fetal & Neonatal Medicine·Louise S OwenPeter G Davis
Jan 9, 2021·The Journal of Pediatrics·Neha KumbhatUNKNOWN Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research Network
Oct 23, 2020·Pediatrics·Sugee Korale LiyanageSarah D McDonald

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Methods Mentioned

BETA
cesarean section

Software Mentioned

GRADEpro Guideline Development Tool
Review Manager
Ovid SP

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