Benefits of using heterologous polyclonal antibodies and potential applications to new and undertreated infectious pathogens

Vaccine
Rashmi DixitRobert Booy

Abstract

Passive immunotherapy using polyclonal antibodies (immunoglobulins) has been used for over a century in the treatment and post-exposure prophylaxis of various infections and toxins. Heterologous polyclonal antibodies are obtained from animals hyperimmunised with a pathogen or toxin. The aims of this review are to examine the history of animal polyclonal antibody therapy use, their development into safe and effective products and the potential application to humans for emerging and neglected infectious diseases. A literature search of OVID Medline and OVID Embase databases was undertaken to identify articles on the safety, efficacy and ongoing development of polyclonal antibodies. The search contained database-specific MeSH and EMTREE terms in combination with pertinent text-words: polyclonal antibodies and rare/neglected diseases, antivenins, immunoglobulins, serum sickness, anaphylaxis, drug safety, post marketing surveillance, rabies, human influenza, Dengue, West Nile, Nipah, Hendra, Marburg, MERS, Hemorrhagic Fever Virus, and Crimean-Congo. No language limits were applied. The final search was completed on 20.06.2015. Of 1960 articles, title searches excluded many irrelevant articles, yielding 303 articles read in full. Of ...Continue Reading

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Citations

Mar 27, 2016·Vaccine·Ricardo PalaciosJorge Kalil
Aug 16, 2016·Cellular Immunology·Braira WahidShazia Rafique
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Sep 24, 2021·Immunity & Ageing : I & a·Nan-Ping Weng, Graham Pawelec

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