Benign Histiocyte-Rich Pseudotumor Developing Postchemotherapy and Mimicking Residual Disease

Case Reports in Pathology
Amrit P SinghSoumya Pandey

Abstract

Histiocyte-rich pseudotumors (HRPT) developing postchemoradiation therapy are a florid response to treatment and reparative change. Although these are benign processes, clinically and radiologically, these may mimic recurrent/relapsed disease. We describe a case of an adult male with history of diffuse large B-cell lymphoma (DLBCL), status postchemoradiation therapy, who developed HRPT at the site of original involvement, mimicking relapse of disease on positron emission tomography/computed tomography (PET/CT) imaging. This is one of the few reported cases of posttreatment HRPT. This entity is important to point out the limitations of PET/CT imaging in patients with lymphomas and metastatic disease and stresses the importance of an excisional biopsy for determining relapse and the need for further treatment.

References

Dec 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A SurboneR C Young
Jun 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G P Canellos
Jul 21, 1994·The New England Journal of Medicine·C L WillmanD G Gilliland
Sep 17, 1998·Archives of Internal Medicine·J CharrowJ S Wisch
May 14, 2003·Archives of Pathology & Laboratory Medicine·Kong-Bing TanGangaraju C Raju
May 16, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Sally F Barrington, Michael J O'Doherty
Oct 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Karen L GroggAntonio G Nascimento
Jan 18, 2006·Journal of Cutaneous Pathology·Brigitte Dreno
Jan 30, 2007·Nature Clinical Practice. Oncology·Tanguy Y SeiwertEverett E Vokes
Oct 17, 2007·Journal of Clinical Pathology·B C Gleason, J L Hornick
Jul 16, 2008·Radiologic Clinics of North America·Matthew J Matasar, Andrew D Zelenetz
Aug 19, 2009·American Journal of Clinical Pathology·Pranil ChandraSherif Ibrahim
Dec 23, 2009·Archives of Otolaryngology--head & Neck Surgery·Daniel J GivensGerry F Funk
Mar 25, 2016·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Lisa SingerSue S Yom
Feb 22, 2017·International Journal of Molecular Sciences·Jérôme StirnemannMarc G Berger
Nov 9, 2018·Archives of Pathology & Laboratory Medicine·Stephanie L SkalaRajan Dewar

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Methods Mentioned

BETA
biopsy
flow cytometry

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