Benign infantile seizures: a prospective study

Epilepsy Research
Alberto Espeche

Abstract

One idiopathic focal epileptic syndrome with onset during infancy is recognized, the benign infantile seizures (BIS). To analyze the electroclinical features and evolution in patients with BIS and assess the difference between familial and non-familial infantile cases. We performed a prospective follow-up study in 41 patients seen at our department between September 2002 and March 2004, with BIS from 2 to 12 months of age. Among the 41 cases 6 were excluded. Thirty five had BIS after the follow-up. The follow-up was 60-77 months (median 69 months). They were divided in Group 1: 14 patients had a family history of similar seizures in infancy and Group 2: 21 without familial history of infantile epilepsy. Both groups have similar electroclinical features and family history of seizures is the only clue to the differential diagnosis. Seizures were brief, and occurred in cluster in 30 patients (85%). Interictal EEGs were normal in 34 cases (97%) and neuroimaging in all children. No one had seizures after finishing the antiepileptic treatment. Neurological examination and developmental milestones remained normal after the follow-up. This study confirms the existence of BIS. Non-familial cases might represent novo mutations or sporadi...Continue Reading

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Citations

Oct 19, 2012·Neurology·Ingrid E SchefferLeanne M Dibbens
Apr 19, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Sook-Cheng Chan, Wang-Tso Lee
Jun 23, 2015·Pediatric Neurology·Kenjiro KikuchiMotoyuki Minamitani
Jul 19, 2011·Seizure : the Journal of the British Epilepsy Association·Alberto EspecheRoberto Horacio Caraballo
Oct 16, 2013·Seizure : the Journal of the British Epilepsy Association·Tingsong LiLi Jiang
May 24, 2021·Seizure : the Journal of the British Epilepsy Association·Josefina de la JaraJuan Moya-Vilches
Jul 24, 2021·Seizure : the Journal of the British Epilepsy Association·Qianlei ZhaoZhongdong Lin
Nov 25, 2021·Journal of Child Neurology·Julio Ramos-LizanaJavier Aguirre-Rodriguez

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