Benign multiple sclerosis is characterized by a stable neuroimmunologic network

Neuroimmunomodulation
Claus G Haase, Pedro M Faustmann

Abstract

Patients diagnosed with multiple sclerosis (MS) but without disability (Expanded Disability Status Scale score <2) form a specific group within those patients suffering from relapsing-remitting MS. Several neuroimmunologic effectors, including cytokines and melatonin, are known for their influence on the initiation of relapses and progression of the disease. We evaluated 41 female patients with benign MS with respect to their clinical course, treatments and neuroimmunological parameters, including cytokines and melatonin. One subgroup was followed up for 7 years, and another group was evaluated during acute clinical relapse. The benign MS course in this homogeneous group of young patients was demonstrated by mild disease progression in 16% over 7 years. Initially, patients treated with azathioprine (AZA) revealed significantly reduced melatonin serum levels (p = 0.04) compared to untreated patients, but not at follow-up. During acute relapse, treatment with corticosteroids (CS) resulted in increased levels of type 2 cytokines as well as reduced type 1 cytokine levels. Our study supports the functional role of CS acting as an antiinflammatory protagonist during MS relapse, by inducing a shift towards predominance of type 2 cytok...Continue Reading

Citations

Jan 13, 2005·European Archives of Psychiatry and Clinical Neuroscience·Michael TinnefeldPedro M Faustmann
Nov 9, 2007·European Archives of Psychiatry and Clinical Neuroscience·Claus G HaasePedro M Faustmann
Apr 16, 2014·Biomedical Journal·Naser FarhadiMohammad Nabiuni
Apr 5, 2008·Journal of Applied Physiology·Vanessa CastellanoLesley J White
Jun 29, 2017·Arquivos de neuro-psiquiatria·Alyne Mendonça Marques TonRegina Maria Papais Alvarenga

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