PMID: 145715Nov 25, 1977Paper

Benign pleural lesion and malignant mesothelioma

Virchows Archiv. A, Pathological Anatomy and Histology
M Klima, F Gyorkey


In a series of eighteen diffuse malignant mesotheliomas, five cases were encountered in which thoracic surgery with benign nontumorous diagnosis preceded the development of a malignant mesothelioma by several years. The morphological findings in three of these five cases are compared with the morphology of the tumor specimens and an attempt is made to recognize the earliest possible malignant features. Crowding of mesothelial cells, their variability in size and nuclear hyperchromatism are pointed out as warning signs. In relation to these findings, the histogenetic significance of predominantly fibroproliferative versus epithelial-like pleural lesions is discussed. A histogenetic classification, based on the studies of eighteen diffuse malignant mesotheliomas, two benign fibrous mesotheliomas, one pleural fibrosarcoma, and numerous pleural plaques as well as reactive mesothelial lesions, is offered. The therapeutic aspects are mentioned.


Dec 1, 1976·Cancer·H J WaneboE J Beattie
Oct 1, 1976·Cancer·J L Kovarik
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May 15, 1976·International Journal of Cancer. Journal International Du Cancer·M J EmbletonR W Baldwin
Jan 1, 1974·Oncology·R E Gerner, G E Moore
Dec 31, 1965·Annals of the New York Academy of Sciences·D O Hourihane
Oct 1, 1960·American Journal of Clinical Pathology·E A FOSTER, L V ACKERMAN
Oct 1, 1963·The Journal of Pathology and Bacteriology·B NAYLOR
May 1, 1976·American Journal of Clinical Pathology·M KlimaW D Seybold

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