PMID: 145715Nov 25, 1977Paper

Benign pleural lesion and malignant mesothelioma

Virchows Archiv. A, Pathological Anatomy and Histology
M Klima, F Gyorkey

Abstract

In a series of eighteen diffuse malignant mesotheliomas, five cases were encountered in which thoracic surgery with benign nontumorous diagnosis preceded the development of a malignant mesothelioma by several years. The morphological findings in three of these five cases are compared with the morphology of the tumor specimens and an attempt is made to recognize the earliest possible malignant features. Crowding of mesothelial cells, their variability in size and nuclear hyperchromatism are pointed out as warning signs. In relation to these findings, the histogenetic significance of predominantly fibroproliferative versus epithelial-like pleural lesions is discussed. A histogenetic classification, based on the studies of eighteen diffuse malignant mesotheliomas, two benign fibrous mesotheliomas, one pleural fibrosarcoma, and numerous pleural plaques as well as reactive mesothelial lesions, is offered. The therapeutic aspects are mentioned.

References

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Citations

Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·K DumkeH Buse
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·I DardickA C Ritchie
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·K F BürrigW Hort
Jun 1, 1982·The Annals of Thoracic Surgery·R W Bunton, J Borrie
Dec 1, 1996·Respirology : Official Journal of the Asian Pacific Society of Respirology·N S Wang
Dec 1, 1981·Thorax·C D SheldonP J Gallagher
Feb 1, 1980·Environmental Health Perspectives·M Kannerstein, J Churg
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·G Mikuz, I Höpfel-Kreiner
Jun 1, 1983·Ultrastructural Pathology·M Klima, M I Bossart
Apr 1, 1990·Pathology, Research and Practice·M BrockmannK M Müller
Jun 26, 2001·Histopathology·J E King, P S Hasleton
Jul 1, 1984·The Journal of Pathology·D Whitaker, K B Shilkin
Feb 1, 1980·British Journal of Industrial Medicine·J C McDonaldA D McDonald
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·M E BoonJ G von Andel

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