PMID: 9185915Jun 1, 1997Paper

Benign polymorphous mesenchymal tumor (mesenchymal hamartoma) of soft parts. Report of two cases

The American Journal of Dermatopathology
M Michal, L Sokol

Abstract

We report two cases of a previously unrecognized neoplasm, each characterized by prominent lobular configuration in the subcutaneous tissue. Within the neoplasms were distinctive garland-shaped structures composed of glial fibrillary acidic protein (GFAP) positive cells with indistinct borders, encased in concentric loops of fine collage fibers. In some areas, the neoplastic cells were distributed in small lacunae. The extracellular space between the collagenous tissue and the cells was filled with copious myxoid matrix. One of the neoplasms also demonstrated areas with spindle cells which resembled leiomyoma. Immunohistochemistry was negative for smooth muscle actin (1A4), muscle actin (HHF35), S-100 protein, desmin, cytokeratin, KP1, and epithelial membrane antigen (EMA.) Currently, both patients are free of recurrence or metastasis 2 and 4 years after primary surgical excision. The neoplasms, which we term benign polymorphous mesenchymal tumor of soft parts (BPMT), should be distinguished from ossifying fibromyxoid tumor of soft parts, extraskeletal mesenchymal chondrosarcoma, neoplasms arising in ectopic breast tissue and mixed tumor of the skin.

References

Oct 1, 1989·The American Journal of Surgical Pathology·F M EnzingerC Y Liang
Jul 1, 1984·The American Journal of Surgical Pathology·J RosaiE M Husband
Jul 1, 1981·The American Journal of Surgical Pathology·R L SirotaR E Scully
Apr 1, 1994·The American Journal of Dermatopathology·O P Sangueza, C R White
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·T IshidaR Machinami

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Citations

Aug 22, 2006·Journal of Cutaneous Pathology·John T SeykoraMicheal Ioffreda
Jul 20, 1999·Dermatologic Clinics·A R Hudson, B R Smoller

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