Benign prostate hyperplasia: evaluation of treatment response with DCE MRI

Magma
Johannes T HeverhagenM V Knopp

Abstract

Benign prostate hyperplasia (BPH) is a major disease and its non-surgical therapy a major area of interest. The purpose of this study was to establish perfusion parameters in beagles with BPH using dynamic contrast-enhanced (DCE) MRI and to investigate changes due to the effects of finasteride treatment. Twelve male beagles (mean age 4.4 +/- 0.9,years) were divided into a control and treatment group that received a daily dose of 1 mg/kg finasteride. DCE MRI was carried out in a clinical scanner using a 3D spoiled gradient echo sequence prior to and during treatment. 0.2 mmol/kg contrast agent (gadoteridol) was administered with an injection rate of 0.2 ml/s followed by a 15 ml flush of saline. Contrast enhancement was evaluated by pharmacokinetic mapping of a two-compartment model with colour overlay images in addition to regional ROI analysis. Quantitative parameters were defined by the amplitude of contrast enhancement A, the exchange rate k(ep) and the time to maximum signal enhancement. Dynamic contrast-enhanced MRI investigations of the prostate revealed two distinct zones, an inner, periurethral zone and an outer, parenchymal zone. The periurethral zone is highly vascularized, whereas the parenchymal zone is moderately va...Continue Reading

References

Sep 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S M CohenE H Cordes
Jul 1, 1991·Journal of Computer Assisted Tomography·G BrixW J Lorenz
Jan 1, 1986·The Prostate·S J BerryD S Coffey
Nov 1, 2001·Topics in Magnetic Resonance Imaging : TMRI·M V KnoppP Choyke
Dec 20, 2002·Current Opinion in Urology·Andrea TubaroLucio Miano
Apr 30, 2003·Journal of Magnetic Resonance Imaging : JMRI·Peter L ChoykeMichael V Knopp

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Citations

Jan 5, 2012·Advances in Urology·Rajakumar NagarajanM Albert Thomas
Dec 15, 2012·Journal of Magnetic Resonance Imaging : JMRI·Olga Rachel BrookRobert E Lenkinski
May 28, 2005·NMR in Biomedicine
Apr 24, 2008·Zeitschrift für Rheumatologie·M SchwarzeC Gutenbrunner

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