PMID: 7541333Jul 1, 1995Paper

Benign prostatic hyperplasia

Disease-a-month : DM
W D Steers, B Zorn

Abstract

Benign prostatic hyperplasia (BPH) is a pathologic disorder that develops in response to the action of dihydrotestosterone on the aging prostate and to changes in stromal and epithelial cells in this exocrine gland. The current therapies for this disorder are chosen after other causes for irritative and obstructive symptoms have been excluded and the status of the urinary tract has been assessed. This evaluation includes a detailed medical history, a thorough genitourinary and neurological examination, assessment of serum prostate specific antigen and creatinine levels, as well as a urinalysis. A urodynamic evaluation consisting of a combined pressure-flow study is required if the diagnosis of obstruction is to be made. Patients with minimal symptoms and normal test results require no therapy. Mild to moderate symptoms can be controlled, at least temporarily, with alpha-adrenergic blockers such as terazosin or doxazosin. A subset of BPH patients with obstructive symptoms respond to the 5 alpha-reductase inhibitor finasteride. Early results with minimally invasive treatments such as laser prostatectomies, hyperthermia, and ultrasonic and radiofrequency ablation appear encouraging for those with moderate symptoms of prostatism. S...Continue Reading

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Citations

Apr 17, 2001·Nursing Research·M GrayW D Steers
Jul 27, 2001·Journal of Clinical Laser Medicine & Surgery·R J Lanzafame
Sep 26, 2013·International Archives of Medicine·Hafiz Muhammad AslamAnum Mughal

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