Benign Solid Thyroid Nodules: US-guided High-Intensity Focused Ultrasound Ablation-Initial Clinical Outcomes

Radiology
Roussanka KovatchevaKatja Zaletel

Abstract

To assess the short-term efficacy and safety of ultrasonographically (US)-guided high-intensity focused ultrasound (HIFU) ablation for treatment of benign solid thyroid nodules. This prospective study was approved by the institutional ethics committee, and written informed consent was acquired. HIFU ablation was performed in one session with US guidance and conscious sedation in 20 euthyroid patients (mean age, 44.5 years) with a benign solitary or dominant thyroid nodule. Thyroid nodule volume, US structure, and Doppler pattern were assessed at baseline, at 1 week, and at 1, 3, and 6 months after treatment. Adverse events associated with HIFU were evaluated. Statistical analysis was conducted by using repeated measures analysis of variance, the Student t test, χ(2) test, and correlation analysis. The mean ± standard deviation nodule volume was 4.96 mL ± 2.79 at the start of the study. Nodule volume had decreased to 3.05 mL ± 1.96 at the 3-month follow-up examination (n = 20, P < .001), and reached 2.91 mL ± 2.43 by the 6-month follow-up examination (n = 16, P < .001). By then, the mean volume reduction was 48.7% ± 24.3 (P < .001). Isoechoic nodules showed greater reduction at 1 month than did hypoechoic nodules (31.6% ± 18.1 v...Continue Reading

Associated Clinical Trials

Jan 6, 2017·Dr. Lang Hung Hin, Brian
Nov 6, 2017·Dr. Lang Hung Hin, Brian

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Citations

Mar 23, 2017·Thyroid : Official Journal of the American Thyroid Association·Brian Hung-Hin LangKeith Wan-Hang Chiu
Jan 14, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Bei WangPing Liang
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian H H LangKeith Wan-Hang Chiu
Jan 14, 2018·European Radiology·Brian H H LangKeith Wan-Hang Chiu
Sep 14, 2017·Physics in Medicine and Biology·C ZachiuB Denis de Senneville
Apr 9, 2015·British Journal of Hospital Medicine·Ros Levenson
Dec 18, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian Hh LangKeith Wan-Hang Chiu
Jul 19, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Adrien Ben HamouHerve Monpeyssen
May 6, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Shi-Hui GuanDeng-Ke Teng
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian H H LangEstella P M Ma
Oct 12, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian H H LangKeith Wan-Hang Chiu
Apr 8, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian H H LangKeith Wan-Hang Chiu
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian H H LangKeith Wan-Hang Chiu
Mar 17, 2017·Journal of Ultrasound·Anna Pisani MaininiGiovanni Mauri
Aug 11, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian H H LangKeith W H Chiu
Aug 5, 2020·Expert Review of Medical Devices·Eleftherios SpartalisNikolaos Nikiteas
May 20, 2017·Journal of Therapeutic Ultrasound·Brian Hung-Hin Lang, Arnold L H Wu
Nov 24, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hervé MonpeyssenEnrico Papini
May 4, 2021·Clinical Endocrinology·Ming-Hsun WuChiung-Nien Chen

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