PMID: 6407402Jul 1, 1983Paper

Benoxaprofen improves psoriasis. A double-blind study

Archives of Dermatology
K Kragballe, T Herlin

Abstract

The pathophysiologic significance of increased levels of lipoxygenase compounds in psoriatic lesions was assessed in a double-blind randomized clinical study with the 5-lipoxygenase inhibitor, benoxaprofen. Forty patients with psoriasis vulgaris were treated with 600 mg of oral benoxaprofen daily or a placebo for a period of eight weeks. Benoxaprofen therapy provided excellent treatment results in about 75% of the cases. In the placebo group, only minimal improvement occurred. Most patients receiving benoxaprofen therapy reported side effects including photosensitivity, onycholysis, milia, diarrhea, and edema. In two cases, benoxaprofen was withdrawn before completion of the treatment course because of photosensitivity. Benoxaprofen may affect psoriatic epidermis either directly by the inhibition of epidermal 5-lipoxygenase or indirectly by the inhibition of the accumulation of phagocytes in psoriatic lesions. Despite serious side effects from benoxaprofen therapy, lipoxygenase-inhibiting agents deserve further study in the treatment of psoriasis.

Citations

Jan 1, 1986·Archives of Dermatological Research·K FoghT Herlin
Jan 1, 1986·Archives of Dermatological Research·J SchnyderA Krebs
Jan 1, 1990·International Journal of Immunopharmacology·B S TehY H Thong
Jun 27, 1998·Clinics in Dermatology·N TsankovK Drenovska
Oct 20, 1999·Journal of Dermatological Science·K Ikai
Jul 17, 2009·The British Journal of Nutrition·P C CalderJ Zhao
Mar 24, 2000·The British Journal of Dermatology·J M MommersP C van de Kerkhof
Nov 28, 1985·The New England Journal of Medicine·D Casareale, D J Volsky
Jan 1, 1996·Clinical and Experimental Dermatology·S G KeohaneN H Cox
May 1, 1983·Journal of the American Academy of Dermatology·C N Ellis, J J Voorhees
Jun 1, 1989·Journal of the American Academy of Dermatology·D F Horrobin
Jul 1, 1984·Journal of the American Academy of Dermatology·R J Coskey
Nov 1, 1984·Journal of the American Academy of Dermatology·D R BickersV A Ziboh
Aug 12, 2003·Arthritis and Rheumatism·Joshua J OfmanPaul G Shekelle
May 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Vasänge-TuominenW Rolfsen
Jun 1, 1988·International Journal of Dermatology·J Fransson, H Hammar
Jul 1, 1985·The British Journal of Dermatology·R D CampM W Greaves
May 1, 1986·The British Journal of Dermatology·P D MauriceP C Bather
Jan 1, 1988·The British Journal of Dermatology·A BjørneboeC A Drevon
Jul 1, 1985·The British Journal of Dermatology·K KragballeJ J Voorhees
Jun 1, 1989·International Journal of Dermatology·H K Schaffer
Sep 1, 1999·Rheumatic Diseases Clinics of North America·D VassilopoulosR M Strauss
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·K Kragballe, J J Voorhees
Aug 23, 2002·The American Journal of Gastroenterology·Walter L StrausPaul Shekelle

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