PMID: 6407032Apr 1, 1983Paper

Benoxaprofen in the treatment of active ulcerative colitis

Prostaglandins, Leukotrienes, and Medicine
C J Hawkey, D S Rampton

Abstract

We have conducted an open pilot trial to assess the therapeutic effect of the lipoxygenase inhibitor, benoxaprofen, in 10 patients with active ulcerative proctocolitis. After 18 days treatment with benoxaprofen (600 mg daily) there was no significant change in bowel habit, rectal bleeding, constitutional upset, sigmoidoscopic appearance, mucosal histology, haemoglobin, ESR, serum albumin or serum orosomucoid. Benoxaprofen itself seems unlikely to prove useful in ulcerative colitis, but evaluation of the therapeutic potential of other lipoxygenase inhibitors in inflammatory bowel disease may be worthwhile.

References

Jun 1, 1979·The Journal of Pharmacy and Pharmacology·S C Meacock, E A Kitchen
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M I SiegelP Cuatrecasas
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Citations

Mar 1, 1988·Digestive Diseases and Sciences·R SchumertR D Zipser
Dec 1, 1984·Gut·D S Rampton, C J Hawkey
Jan 1, 1992·Mediators of Inflammation·N A PunchardR P Thompson
Dec 14, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Kohsuke Uchida, Yuichiro Kamikawa
Dec 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D J FretlandT S Gaginella
Jan 1, 1983·Avian Pathology : Journal of the W.V.P.A·C HawkeyD M Jones
Jul 27, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A P R PaiottiM Franco
Oct 26, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V TakafujiJ K Roche

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