Abstract
BEN/SC1/DM-GRASP is a membrane glycoprotein of the immunoglobulin superfamily isolated in the chick by several groups, including ours. Its expression is strictly developmentally regulated in several cell types of the nervous and hemopoietic systems and in certain epithelia. Each of these cell types expresses isoforms of BEN which differ by their level of N-glycosylation and by the presence or absence of the HNK-1 carbohydrate epitope. In the present work, the influence of glycosylation on BEN homophilic binding properties was investigated by two in vitro assays. First, each BEN isoform was covalently coupled to microspheres carrying different fluorescent dyes and an aggregation test was performed. We found that homophilic aggregates form indifferently between the same or different BEN isoforms, showing that glycosylation does not affect BEN homophilic binding properties. This was confirmed in the second test, where the BEN-coated microspheres bound to the neurites of BEN- expressing neurons, irrespective of the isoform considered. The transient expression of the BEN antigen on hemopoietic progenitors prompted us to see whether it might play a role in their proliferation and differentiation. When added to hemopoietic progenitor ...Continue Reading
References
Jul 1, 1992·Journal of Neuroscience Research·M BarbuJ Smith
Apr 15, 1992·Cellular Immunology·C CorbelN M Le Douarin
Aug 21, 1992·Brain Research. Developmental Brain Research·J T PrinceW B Stallcup
Nov 1, 1992·Experimental Cell Research·C CorbelH G Bluestein
May 1, 1992·The Journal of Cell Biology·K A PaschkeC A Stuermer
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·O PourquiéN M Le Douarin
Apr 5, 1991·Cell·B PainP Jurdic
Nov 1, 1991·The Journal of Cell Biology·T B KuhnP Sonderegger
Jan 1, 1992·Developmental Biology·S el-DeebJ Covault
Aug 1, 1991·Neuron·F R BurnsS Chang
Oct 1, 1991·Neuron·H TanakaD L Shelton
Aug 1, 1990·Development·O PourquiéN M Le Douarin
Jan 1, 1988·The Journal of Cell Biology·V KünemundM Schachner
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J M LehmannJ P Johnson
Oct 1, 1988·Veterinary Immunology and Immunopathology·S H JeurissenG F De Boer
Dec 1, 1993·Genes & Development·R G RamosK F Fischbach
Feb 1, 1995·The European Journal of Neuroscience·A ChédotalC Sotelo
Jun 1, 1995·The Journal of Experimental Medicine·M A BowenU Francke
Jul 1, 1994·Experimental Cell Research·A S Lacoste-EleaumeC Kanellopoulos-Langevin
Apr 1, 1994·Differentiation; Research in Biological Diversity·U LaessingC A Stuermer
Jul 1, 1994·Journal of Neurobiology·J P KankiJ Y Kuwada
Apr 1, 1994·Neuron·E TairaN Miki
Citations
Feb 26, 2000·Developmental and Comparative Immunology·C Siatskas, R Boyd
Apr 27, 2000·Experimental Hematology·J M NelissenC G Figdor
Feb 19, 2011·Avian Pathology : Journal of the W.V.P.A·Ekowati HandharyaniYasuhiro Tsukamoto
Apr 26, 2013·Current Opinion in Hematology·Brahmananda R ChittetiEdward F Srour
Dec 4, 2010·BMC Molecular Biology·Fang TanSolomon F Ofori-Acquah
Aug 21, 2004·Breast Cancer Research : BCR·Judy A KingWen G Jiang
Nov 9, 2000·Cellular Immunology·W T Weber
Dec 2, 2015·Oncology Letters·Yuka KubotaYasuhiro Tsukamoto
Jan 3, 2013·Stem Cells·Robin JeannetYa-Huei Kuo
Sep 4, 2004·Molecular and Cellular Neurosciences·Joshua A WeinerJoshua R Sanes
Nov 21, 2000·Seminars in Immunology·D Dunon, B A Imhof
Jul 5, 2008·Developmental Biology·Susanne GessertMichael Kühl
Jul 15, 2000·Baillière's Best Practice & Research. Clinical Haematology·S F ParsonsD J Anstee
Sep 7, 2007·PLoS Biology·Catherine A LeameyReinhard Fässler
Sep 28, 2016·PloS One·YeonSung SonJe-Yoel Cho
Jul 25, 2000·Mechanisms of Development·S FrabouletO Pourquié
Mar 17, 1997·The Journal of Comparative Neurology·D KaragogeosO Pourquié
May 2, 2001·The Journal of Comparative Neurology·R J GoodyearG P Richardson
Jun 1, 1997·European Journal of Immunology·M A BowenA Aruffo
Jul 9, 2009·Acta Veterinaria Hungarica·Ildikó BódiImre Oláh
Sep 25, 2001·Blood·O OhnedaT Suda
Jan 16, 2020·PeerJ·Li PiJing Du
Apr 26, 2014·Development·Wiebke CizelskySusanne J Kühl
Jun 24, 2021·The Journal of Experimental Medicine·Shoubao MaJianhua Yu
Jul 13, 2002·European Journal of Cell Biology·Guido W M Swart