PMID: 8610129Apr 2, 1996Paper

BEN/SC1/DM-GRASP, a homophilic adhesion molecule, is required for in vitro myeloid colony formation by avian hemopoietic progenitors

Proceedings of the National Academy of Sciences of the United States of America
C CorbelN M Le Douarin

Abstract

BEN/SC1/DM-GRASP is a membrane glycoprotein of the immunoglobulin superfamily isolated in the chick by several groups, including ours. Its expression is strictly developmentally regulated in several cell types of the nervous and hemopoietic systems and in certain epithelia. Each of these cell types expresses isoforms of BEN which differ by their level of N-glycosylation and by the presence or absence of the HNK-1 carbohydrate epitope. In the present work, the influence of glycosylation on BEN homophilic binding properties was investigated by two in vitro assays. First, each BEN isoform was covalently coupled to microspheres carrying different fluorescent dyes and an aggregation test was performed. We found that homophilic aggregates form indifferently between the same or different BEN isoforms, showing that glycosylation does not affect BEN homophilic binding properties. This was confirmed in the second test, where the BEN-coated microspheres bound to the neurites of BEN- expressing neurons, irrespective of the isoform considered. The transient expression of the BEN antigen on hemopoietic progenitors prompted us to see whether it might play a role in their proliferation and differentiation. When added to hemopoietic progenitor ...Continue Reading

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Citations

Feb 26, 2000·Developmental and Comparative Immunology·C Siatskas, R Boyd
Apr 27, 2000·Experimental Hematology·J M NelissenC G Figdor
Apr 26, 2013·Current Opinion in Hematology·Brahmananda R ChittetiEdward F Srour
Dec 4, 2010·BMC Molecular Biology·Fang TanSolomon F Ofori-Acquah
Aug 21, 2004·Breast Cancer Research : BCR·Judy A KingWen G Jiang
Nov 21, 2000·Seminars in Immunology·D Dunon, B A Imhof
Jul 15, 2000·Baillière's Best Practice & Research. Clinical Haematology·S F ParsonsD J Anstee
Jul 25, 2000·Mechanisms of Development·S FrabouletO Pourquié
May 2, 2001·The Journal of Comparative Neurology·R J GoodyearG P Richardson
Jul 9, 2009·Acta Veterinaria Hungarica·Ildikó BódiImre Oláh
Apr 26, 2014·Development·Wiebke CizelskySusanne J Kühl
Jun 24, 2021·The Journal of Experimental Medicine·Shoubao MaJianhua Yu

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