Benserazide as a potential novel fetal hemoglobin inducer: an observational study in non-carriers of hemoglobin disorders.

Blood Cells, Molecules & Diseases
Marina Erê Hummel Pimenta SantosKleber Yotsumoto Fertrin

Abstract

Induction of fetal hemoglobin production with hydroxyurea is an effective strategy in sickle cell disease and beta thalassemias, but up to 20% of patients do not respond to or cannot tolerate it. Benserazide is used in the treatment of Parkinson's disease and was noticed to induce gamma globin in preclinical models. We hypothesized that chronic treatment with benserazide-containing medication may be associated with increase in HbF production and in circulating F-cells. Blood samples were collected from 50 subjects including 35 patients on benserazide for Parkinson's disease, 10 healthy controls, and 5 patients with sickle cell anemia as positive controls for high fetal hemoglobin. We found a strong correlation between HbF and circulating F-cells in the entire population, but we found no significant increase in HbF and F-cell percentage in patients taking benserazide up to 700 mg daily. No hematologic abnormalities attributable to benserazide use after up to 22 years were detected. Our data support long-term safety and tolerability of benserazide at doses ten times higher than used in preclinical models to induce fetal hemoglobin. Further clinical trials enrolling patients with sickle cell disease and thalassemia are warranted t...Continue Reading

References

Aug 22, 2003·European Journal of Haematology·Ilaria LamprontiRoberto Gambari
Apr 18, 2009·Journal of Agricultural and Food Chemistry·Alessandra GuerriniMonica Borgatti
May 20, 2015·Molecular and Cellular Biology·Yu-Chi ChouChe-Kun James Shen
Mar 10, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N GaudreA Del Bello
Jul 1, 2018·Seminars in Hematology·Donald LavelleYogen Saunthararajah

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Citations

Jul 21, 2021·International Journal of Molecular Sciences·Filomena LongoAntonio Piga
Aug 5, 2021·American Journal of Hematology·Khaled M MusallamAli T Taher

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