Benzamil blockade of brain Na+ channels averts Na(+)-induced hypertension in rats

The American Journal of Physiology
M NishimuraM Yoshimura

Abstract

To determine the possible involvement of brain amiloride-sensitive Na+ channels in Na(+)-induced hypertension, we investigated the effects of benzamil hydrochloride, a specific blocker of these Na+ channels, on the acute pressor mechanisms of intracerebroventricular infusion of hypertonic NaCl and the continuous pressor mechanisms of Na(+)-induced chronic hypertension, such as deoxycorticosterone acetate-salt hypertensive or stroke-prone spontaneous hypertensive rats, and of non-Na(+)-induced hypertension, such as renovascular hypertensive rats. Intracerebroventricular preinjection with benzamil (1 or 10 nmol/kg) abolished the increase in mean arterial pressure, heart rate, abdominal sympathetic discharge, and plasma vasopressin concentration induced by an acute increase in cerebrospinal Na+ concentrations at intracerebroventricular infusion of 1.5 M hypertonic NaCl. Continuous intracerebroventricular infusion of benzamil (1 or 10 nmol.kg-1.day-1) for 7 days attenuated Na(+)-induced chronic hypertension in both deoxycorticosterone acetate-salt and stroke-prone spontaneous hypertensive rats, accompanied by reduction of urinary excretion of vasopressin and norepinephrine but not in renovascular hypertensive rats. Intravenous infu...Continue Reading

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Citations

Aug 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hao WangFrans H H Leenen
Jul 10, 2012·Journal of Applied Physiology·Alexander Gabor, Frans H H Leenen
Nov 3, 2011·American Journal of Physiology. Endocrinology and Metabolism·Ryoichi TeruyamaWilliam E Armstrong
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B S HuangF H Leenen
Oct 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joanna M AbramsJohn W Osborn
May 6, 2009·Acta neurochirurgica·Endre SulyokTamás Dóczi
Jun 14, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John P CollisterJohn W Osborn
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Q H Chen, G M Toney
Nov 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Mordecai P BlausteinW Gil Wier
Jul 7, 2010·The Journal of Physiology·Glenn M Toney, Sean D Stocker
Sep 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rebecca L MillerArthur D Loewy
Apr 4, 2021·International Journal of Molecular Sciences·Wakako Kawarazaki, Toshiro Fujita

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