PMID: 8609080Jan 1, 1996Paper

Benzastatins A, B, C, and D: new free radical scavengers from Streptomyces nitrosporeus 30643. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

The Journal of Antibiotics
Won-Gon KimI D Yoo

Abstract

In the course of screening for free radical scavengers, rare metabolites, benzastatins A and B having aminobenzamide skeleton and benzastatins C and D having tetrahydroquinoline skeleton, were isolated from the culture broth of streptomyces nitrosporeus 30643. They showed inhibitory activity against lipid peroxidation in rat liver microsomes. In the cell assay, benzastatins C and D inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 2.0 and 5.4 microM, respectively.

Citations

Feb 11, 2005·Natural Product Research·Jerzy W JaroszewskiBrinda Somanadhan
Jan 9, 2007·Biotechnology Letters·Hung Bae Chang, Jae-Heon Kim
Sep 14, 2017·Medicinal Research Reviews·Xiao-Fei ShangKuo-Hsiung Lee
Jul 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeysson Sánchez-SuárezLuis Díaz
Jun 17, 2010·The Journal of Antibiotics·Motoki TakagiKazuo Shin-Ya
May 10, 2016·Chemical Communications : Chem Comm·Yuan-Ming SunMin Shi
Apr 25, 2019·Bioscience, Biotechnology, and Biochemistry·Yohei Katsuyama
Jun 24, 2017·Chemistry : a European Journal·Ahmad S AltitiYousef Al-Abed
Nov 11, 2020·Natural Product Reports·Jeffrey D RudolfZining Li
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José CleriguéJ Carlos Menéndez
Aug 13, 2011·Chemical Reviews·Vellaisamy SridharanJ Carlos Menéndez
May 3, 2018·Journal of the American Chemical Society·Hayama TsutsumiYasuo Ohnishi
Oct 14, 2014·The Journal of Organic Chemistry·Gong-Qing Liu, Yue-Ming Li
Jan 19, 2018·The Journal of Organic Chemistry·Duanyang KongJiaxin Zhang

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