PMID: 6353911Jan 1, 1983Paper

Benzene: a multipotential carcinogen. Results of long-term bioassays performed at the Bologna Institute of Oncology

American Journal of Industrial Medicine
C MaltoniG Cotti

Abstract

Until recently, the incidence of benzene carcinogenicity was based only on the association between benzene occupational exposure and human leukemia, with many limited case reports and scanty epidemiological data. Available experimental studies up to 1976 on animals were rare, fragmentary, and inadequate, and had failed to prove the carcinogenic effects of benzenes. However, an integrated project of long-term carcinogenicity bioassays, begun in our laboratory in 1976 and still continuing, has shown that benzene produces a variety of tumors in rats including Zymbal gland carcinomas, carcinomas of the oral cavity, hepatocarcinomas, and possibly mammary carcinomas, lymphoreticular neoplasias, and other malignancies. Some of the tumors caused by benzene are uncommon or unusual in the breed of rats studied. Therefore benzene must be considered, under the studied experimental conditions, a strong multipotential carcinogen. The need for more experimental research is emphasized, particularly to assess the carcinogenic effects of low doses. Also recommended are more comprehensive epidemiological investigations, extended to all types of malignancies, and the application of adequate measures for primary prevention.

References

Jul 9, 1977·Lancet·P F InfanteR J Young
Jan 1, 1976·Annals of the New York Academy of Sciences·E C VIGLIANI
Mar 1, 1971·Archives of Environmental Health·A ForiA Limonta
Nov 1, 1971·Archives of Environmental Health·A M ForniE C VIGLIANI
Mar 1, 1971·American Journal of Epidemiology·T IshimaruM Ichimaru
Aug 1, 1982·Annals of Internal Medicine·L Rosenstock
Jan 1, 1982·American Journal of Industrial Medicine·C MaltoniA Mandrioli
Jan 1, 1981·American Journal of Industrial Medicine·R A RinskyA B Smith
Feb 6, 1978·Health Care Management Review·G Levin
Oct 22, 1964·The New England Journal of Medicine·E C VIGLIANI, G SAITA

Citations

Nov 1, 1989·Cell Biology and Toxicology·A J Bailer, D G Hoel
Dec 31, 2009·Bulletin of Mathematical Biology·Cammey C ManningHien T Tran
Sep 11, 1991·Mutation Research·M S Legator, J B Ward
Dec 1, 1984·The Science of the Total Environment·L Fishbein
Jun 1, 1994·Mutation Research·D McGregor
Apr 1, 1985·Toxicology Letters·T H ConnorT S Matney
May 29, 2004·Mutation Research·John WhysnerElizabeth A Lax
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L LatrianoG Witz
Jul 1, 1994·Journal of Toxicology and Environmental Health·A BartczakW E Bechtold
Mar 1, 2013·Food Additives & Contaminants. Part B, Surveillance·Ruziye Cakir, Arzu Cagri-Mehmetoglu
Feb 24, 1998·Annals of the New York Academy of Sciences·C Maltoni
Oct 1, 1988·British Journal of Industrial Medicine·A Yardley-JonesM J Davies
Aug 1, 1988·British Journal of Industrial Medicine·A Yardley-JonesP Jenkinson
Dec 1, 1989·British Journal of Industrial Medicine·G M Swaen, J M Meijers
Jul 1, 1989·Environmental Health Perspectives·A J Bailer, D G Hoel
Jul 1, 1989·Environmental Health Perspectives·W J Nicholson, P J Landrigan
Jul 1, 1989·Environmental Health Perspectives·R A Rinsky
Jul 1, 1989·Environmental Health Perspectives·S M BrettV M Chinchilli
Dec 1, 1993·Environmental Health Perspectives·D J PaustenbachP Price
Dec 1, 1996·Environmental Health Perspectives·R F Henderson
Dec 1, 1996·Environmental Health Perspectives·B T Tunca, U Egeli
Apr 1, 1993·Environmental Health Perspectives·R SnyderB D Goldstein
Dec 1, 1996·Environmental Health Perspectives·F A AngelosantoC R Mackerer
Aug 28, 2007·International Journal of Occupational and Environmental Health·James Huff
Jan 1, 1994·Critical Reviews in Toxicology·R Snyder, G F Kalf
Mar 1, 1990·Toxicology and Applied Pharmacology·C C TravisA D Arms
Jun 15, 1988·Toxicology and Applied Pharmacology·P J SabourinR F Henderson
Sep 20, 2000·Redox Report : Communications in Free Radical Research·U BurnerC Obinger
Jun 20, 2002·Critical Reviews in Toxicology·R Snyder
Jan 1, 1990·Annals of the New York Academy of Sciences·B D Goldstein
Jan 1, 1984·Toxicologic Pathology·J D WilbournR Montesano
Nov 22, 2008·Toxicology and Industrial Health·S WilburO Faroon
Mar 1, 1995·Toxicology and Industrial Health·C Maltoni, M Soffritti
Dec 1, 1988·Toxicology and Industrial Health·H M KipenB D Goldstein
Sep 1, 1995·Journal of Applied Toxicology : JAT·N R Rao, R Snyder
Jan 1, 1991·American Journal of Industrial Medicine·M A Mehlman
Jan 1, 1983·American Journal of Industrial Medicine·B D Goldstein
Jan 1, 1985·American Journal of Industrial Medicine·B Holmberg, P Lundberg
Jan 1, 1984·American Journal of Industrial Medicine·C A SnyderR E Albert
Jan 1, 1987·Critical Reviews in Toxicology·G F Kalf
Nov 17, 2017·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Chitsan LinMaria Ching Villanueva
Apr 23, 1987·The New England Journal of Medicine·R A RinskyP J Landrigan
Jan 1, 1988·Annals of the New York Academy of Sciences·C MaltoniV Di Maio
Jan 1, 1986·Environmental Mutagenesis·G L ErexsonA D Kligerman
Oct 15, 1987·The New England Journal of Medicine·A Wasserstein, C Kelly
Dec 17, 1997·Toxicology and Industrial Health·G L Gist, J R Burg
May 1, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Francesco TomeiSerafino Ricci
Feb 4, 2003·Annals of the New York Academy of Sciences·Lorenzo Tomatis
Mar 14, 2017·The Science of the Total Environment·Katherine M KinderThomas M Hughes
Jan 13, 2001·Chemico-biological Interactions·D J Long, A K Jaiswal

Related Concepts

Benzene
Marrow
Medicinal Plants Testing, Preclinical
Cricetus
Leukemia
Leukemia, Experimental
Malignant Neoplasms

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.