Benzene adducts with rat nucleic acids and proteins: dose-response relationship after treatment in vivo.

Environmental Health Perspectives
M MazzulloS Parodi

Abstract

The dose-response relationship of the benzene covalent interaction with biological macromolecules from rat organs was studied. The administered dose range was 3.6 x 10(7) starting from the highest dosage employed, 486 mg/kg, which is oncogenic for rodents, and included low and very low dosages. The present study was initially performed with tritium-labeled benzene, administered by IP injection. In order to exclude the possibility that part of the detected radioactivity was due to tritium incorporated into DNA from metabolic processes, 14C-benzene was then also used following a similar experimental design. By HPLC analysis, a single adduct from benzene-treated DNA was detected; adduct identification will be attempted in the near future. Linear dose-response relationship was observed within most of the range of explored doses. Linearity was particularly evident within low and very low dosages. Saturation of benzene metabolism did occur at the highest dosages for most of the assayed macromolecules and organs, especially in rat liver. This finding could be considered as indicative of the dose-response relationship of tumor induction and could be used in risk assessment.

References

Oct 15, 1978·International Journal of Cancer. Journal International Du Cancer·D H PhillipsP Sims
Nov 1, 1977·Chemico-biological Interactions·W K Lutz, C Schlatter
Jul 1, 1989·Environmental Health Perspectives·S ParodiS Grilli
Aug 1, 1987·Environmental Health Perspectives·L ZeiseE A Crouch
Apr 23, 1987·The New England Journal of Medicine·R A RinskyP J Landrigan
Jan 1, 1987·Archives of Toxicology·R SnyderT Rushmore
Apr 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·N Kinoshita, H V Gelboin

❮ Previous
Next ❯

Citations

Dec 1, 1994·Mutation Research·M V ReddyC R Mackerer
Jul 1, 1989·Environmental Health Perspectives·S ParodiS Grilli
Dec 1, 1996·Environmental Health Perspectives·R Snyder, C C Hedli
Nov 13, 2002·Mutation Research·William W AuCarsten Harms
Dec 26, 2009·Chemico-biological Interactions·Scott Mondrala, David A Eastmond
Aug 27, 2013·Pharmacology & Therapeutics·Ivan RusynKathryn Z Guyton
Nov 22, 2008·Toxicology and Industrial Health·S WilburO Faroon
Jan 12, 2000·The Journal of Pathology·S R O'ConnorI Lauder
Jan 26, 2013·Critical Reviews in Toxicology·Scott M ArnoldA Robert Schnatter
Sep 18, 2020·Toxicology Letters·Colin M NorthStephen D Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.