PMID: 3755290Aug 1, 1986Paper

Benzene modulation of liver cell structure and heme-cytochrome P-450 metabolism

The American Journal of the Medical Sciences
N G AbrahamR D Levere

Abstract

Rats were treated with subcutaneous benzene, 440 mg/kg, for 3 and 14 days (acute and chronic exposure). Their hepatic cell heme and drug metabolizing enzymes as well as cell morphology by electron microscopy were examined. Electron micrographs of hepatocytes from the benzene-treated rats showed disruption of the mitochondrial membranes and mitochondrial structure. The activity of the rate-limiting enzyme of heme synthesis, delta-aminolevulinic acid synthase was increased 1.5-2-fold in both acutely and chronically exposed animals. In the acutely exposed animals, there was a 50% inhibition of the second enzyme of heme synthesis, delta-aminolevulinic acid dehydratase, while in the chronically exposed there was 70% inhibition. The rate-limiting enzyme of heme degradation, heme oxygenase, was increased more than twofold in both sets of animals. Cytochrome P-450 content was increased 77% in the acutely treated and 35% in the chronic. Associated with this increase in cytochrome P-450 content, there was a twofold increase in both arylhydrocarbon hydroxylase and aminopyrine-N-demethylase activities after acute exposure. During chronic exposure, however, there was a return to normal of the aminopyrine-N-demethylase activity and a decline...Continue Reading

References

Jan 1, 1979·Pharmacology & Therapeutics·F P Guengerich
Dec 1, 1979·Toxicology and Applied Pharmacology·R D IronsK A Muirhead
Jun 1, 1975·CRC Critical Reviews in Toxicology·R Snyder, J J Kocsis
Jun 1, 1982·Environmental Research·D L DresnerR D Levere
Feb 1, 1981·Journal of Toxicology and Environmental Health·S L LongacreR Snyder

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Citations

May 1, 1991·International Journal of Cell Cloning·N G AbrahamJ D Lutton
Jan 1, 1988·The International Journal of Biochemistry·N G AbrahamS Shibahara
Jul 1, 1990·The Journal of Clinical Investigation·R D LevereN G Abraham
Dec 1, 1988·The American Journal of the Medical Sciences·K SolangiR D Levere
Sep 1, 1988·The American Journal of the Medical Sciences·S M MitrioneN G Abraham
Mar 1, 1991·Journal of Hepatology·D SacerdotiJ C McGiff
Jul 16, 2016·Prostaglandins & Other Lipid Mediators·Shailendra P SinghLars Bellner
May 1, 1989·Archives of Biochemistry and Biophysics·J H LinN G Abraham
Apr 8, 2006·Physiological Reviews·Stefan W RyterAugustine M K Choi
Jan 1, 1994·Bulletin of Environmental Contamination and Toxicology·S T McMurryC W Qualls
Dec 15, 1988·Biochemical and Biophysical Research Communications·P MartasekN G Abraham
Jan 1, 1990·Kidney International·M L SchwartzmanN G Abraham

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