Benzimidazole derivatives protect against cytokine-induced apoptosis in pancreatic β-Cells

Bioorganic & Medicinal Chemistry Letters
Nik Khairunissa Nik Abdullah ZawawiM Iqbal Choudhary

Abstract

Apoptotic cell death is the cause of the loss of insulin-producing β-cells in all forms of diabetes mellitus. The identification of small molecules capable of protecting cytokine-induced apoptosis could form the basis of useful therapeutic interventions. Here in, we present the discovery and synthesis of new benzimidazole derivatives, capable of rescuing pancreatic β-cells from cytokine-induced apoptosis. Three hydrazone derivatives of benzimidazole significantly increased the cellular ATP levels, reduced caspase-3 activity, reduced nitrite production and increased glucose-stimulated insulin secretion in the presence of proinflammatory cytokines. These findings suggest that these compounds may protect β-cells from the harmful effects of cytokines and may serve as candidates for therapeutic intervention for diabetes.

Citations

Jan 4, 2017·Bioorganic Chemistry·Nik Khairunissa Nik Abdullah ZawawiFazal Rahim
Apr 11, 2019·Mini Reviews in Medicinal Chemistry·Pelin Çıkla-Süzgün, Ş Güniz Küçükgüzel

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