Abstract
CYP1A2, a principal catalyst for metabolism of various therapeutic drugs and carcinogens, among others, is in part regulated by the stress response. This study was designed to assess whether catecholamines and in particular adrenergic receptor-dependent pathways, modulate benzo(alpha)pyrene (B(alpha)P)-induced hepatic CYP1A2. To distinguish between the role of central and peripheral catecholamines in the regulation of CYP1A2 induction, the effect of central and peripheral catecholamine depletion using reserpine was compared to that of peripheral catecholamine depletion using guanethidine. The effects of peripheral adrenaline and L-DOPA administration were also assessed. The results suggest that alterations in central catecholamines modulate 7-methoxyresorufin O-demethylase activity (MROD), CYP1A2 mRNA and protein levels in the B(alpha)P-induced state. In particular, central catecholamine depletion, dexmedetomidine-induced inhibition of noradrenaline release and blockade of alpha(1)-adrenoceptors with prazosin, up-regulated CYP1A2 expression. Phenylephrine and dexmedetomidine-induced up-regulation may be mediated, in part, via peripheral alpha(1)- and alpha(2)-adrenoceptors, respectively. On the other hand, the L-DOPA-induced in...Continue Reading
References
May 1, 1976·Neurology·A Barbeau, M Roy
Jan 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P Soucek, I Gut
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·E O JohnsonP W Gold
Feb 6, 1990·European Journal of Pharmacology·M KouluR Virtanen
Jan 1, 1990·Drug Metabolism Reviews·C Ioannides, D V Parke
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·G B Glavin
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K SogawaY Fujii-Kuriyama
Feb 1, 1981·Journal of Neuroscience Methods·I N Mefford
Aug 30, 1982·Life Sciences·J A MattheijJ J Swarts
Jun 1, 1994·Pharmacogenetics·U Fuhr, K L Rost
Jun 1, 1997·Environmental Health Perspectives·O Pelkonen, H Raunio
May 14, 1999·European Journal of Drug Metabolism and Pharmacokinetics·M KonstandiM Marselos
Oct 13, 1999·Mutation Research·F P GuengerichP D Josephy
Dec 22, 1999·Biochemical Pharmacology·D W NebertT P Dalton
Aug 18, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M KonstandiM Marselos
Jan 6, 2001·Toxicology and Applied Pharmacology·S H CherngH Lee
Mar 29, 2002·The Annals of Pharmacotherapy·Josep M LlibreGuillem Sirera
Sep 5, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·W A DanielA Haduch
Jun 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Marco Aurelio de Paula Brotto
Dec 12, 2003·Biochemical Pharmacology·Shilpa G LalchandaniDennis R Feller
Jan 17, 2004·Chemico-biological Interactions·Maria KonstandiMatti A Lang
Jan 4, 2005·Biochemical Pharmacology·Maria KonstandiMatti Alarik Lang
Citations
Mar 1, 2013·Molecular Neurobiology·Anshuman SinghDevendra Parmar
Jul 10, 2013·Expert Opinion on Drug Metabolism & Toxicology·Maria Konstandi
Jul 12, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marta Kot, Władysława A Daniel
Nov 9, 2007·Life Sciences·Maria KonstandiMatti A Lang
Aug 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael KollerUNKNOWN EORTC Quality of Life Group
Nov 2, 2007·Basic & Clinical Pharmacology & Toxicology·Maria KonstandiMarios Marselos
Oct 16, 2015·PloS One·P HarkitisM Konstandi
Sep 18, 2008·Journal of Applied Toxicology : JAT·Maria KonstandiCharis Liapi
Apr 19, 2012·American Journal of Physiology. Endocrinology and Metabolism·Evangelos P DaskalopoulosMaria Konstandi
Jul 10, 2012·Molecular Pharmacology·Evangelos P DaskalopoulosMaria Konstandi
Jun 25, 2021·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Foteini MalliouMaria Konstandi