Abstract
Numerous reports indicate that carcinogenic polycyclic aromatic hydrocarbons (PAH) are mammalian immunotoxicants. These environmental contaminants are widely distributed in both freshwater and costal marine ecosystems where they have been found to bioaccumulate in aquatic species, yet limited information exists regarding potential adverse effects of specific PAH on fish immune function. In the present report, Oreochromis niloticus fish (tilapia) were exposed by intraperitoneal injection to 5, 25, or 50 mg/kg of the PAH, benzo[a]pyrene (B[a]P). Histopathologic evaluation of the primary hematopoietic compartment of fish, the pronephros, demonstrated increased vacuolation of both stromal and parenchymal cells, reduction of lymphoid elements, and immune cell apoptosis. Total pronephros cell counts were diminished in a dose-dependent manner by the chemical exposure. The oxidative metabolic burst in phorbol myristate acetate (PMA)-simulated macrophages isolated from the pronephros was significantly inhibited by B[a]P, but only at the highest dose level employed. The phagocytic capacity of pronephros macrophages was not altered by the chemical treatment.
References
Dec 1, 1992·Toxicology and Applied Pharmacology·J A HardinD H Sherr
Oct 11, 1992·Toxicology and Applied Pharmacology·G S LadicsK L White
Aug 11, 1991·Toxicology and Applied Pharmacology·G S LadicsK L White
May 1, 1990·The Science of the Total Environment·A E MaccubbinB P Dunn
May 1, 1988·Toxicology and Applied Pharmacology·L M ThurmondJ H Dean
Jan 1, 1986·International Journal of Immunopharmacology·E C WardJ H Dean
Sep 1, 1987·Immunopharmacology·P Urso, R A Johnson
Oct 1, 1985·Carcinogenesis·D C MalinsS L Chan
Jan 1, 1984·Journal of Toxicology and Environmental Health·P Urso, N Gengozian
Oct 1, 1982·Journal of Toxicology and Environmental Health·P Urso, N Gengozian
Jul 1, 1994·Journal of Toxicology and Environmental Health·S D Holladay, B J Smith
Feb 1, 1993·Cancer Letters·J D KellyD E Williams
Mar 28, 1997·Toxicology·L J HartS D Holladay
Mar 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·R A MALMGRENT W McKINLEY
Citations
May 8, 2004·Aquatic Toxicology·S ReynaudP Deschaux
Oct 17, 2001·Developmental and Comparative Immunology·D L EvansL Jaso-Friedmann
Oct 17, 2001·Developmental and Comparative Immunology·N C BolsL E Lee
Mar 10, 2001·Aquatic Toxicology·W L RoseM Faisal
Feb 22, 2002·Aquatic Toxicology·E A CarlsonJ T Zelikoff
Nov 18, 2005·Journal of Toxicology and Environmental Health. Part a·Ketil Hylland
Apr 1, 2005·Journal of Toxicology and Environmental Health. Part a·Kendra F GoffKeith A Grasman
Aug 10, 2007·Journal of Toxicology and Environmental Health. Part a·Lee A FrederickCharles D Rice
Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ayako NakayamaHelmut Segner
Jan 1, 2008·The Journal of Parasitology·Claudia Sanchez-RamirezBernd Sures
Apr 15, 2007·Pakistan Journal of Biological Sciences : PJBS·M A HassanainWafaa T Abbas
Sep 12, 2015·Journal of Immunotoxicology·Rezvan TaheriAbdolali Movahedinia
Sep 30, 2014·Environmental Toxicology·Maryam KhaniyanAbdolali Movahedinia
Dec 30, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Bado-NillesS Le Floch
Feb 3, 2009·Marine Environmental Research·Ke-Jian WangJian-Jun Yuan
Nov 21, 2007·Environmental Pollution·Christopher J Kennedy, Anthony P Farrell
Nov 3, 2004·Toxicology and Applied Pharmacology·E A CarlsonJ T Zelikoff
Mar 30, 2000·Cytometry·R M GogalS D Holladay
Apr 11, 2020·Scientific Reports·Justin P LewisWilliam F Patterson
Feb 6, 2020·Scientific Reports·Maria L RodgersRobert J Griffitt
Mar 30, 2021·Marine Pollution Bulletin·Arno BringerHélène Thomas
Dec 15, 2020·Aquatic Toxicology·Maria L RodgersDana L Wetzel
Jun 22, 2005·Aquatic Toxicology·C A Oliveira RibeiroH Roche
Nov 9, 2018·The Science of the Total Environment·You SongKnut Erik Tollefsen