Benzodiazepine and Z-drug prescribing in Ireland: analysis of national prescribing trends from 2005 to 2015

British Journal of Clinical Pharmacology
C CadoganKathleen Bennett

Abstract

The aim of this study was to examine prescribing trends for benzodiazepines and Z-drugs to General Medical Services (GMS) patients in Ireland. A repeated cross-sectional analysis of the national pharmacy claims database was conducted for GMS patients aged ≥16 years from 2005 to 2015. Prescribing rates per 1000 eligible GMS population were calculated with 95% confidence intervals (CIs). Negative binomial regression was used to determine longitudinal trends and compare prescribing rates across years, gender and age groups. Duration of supply and rates of concomitant benzodiazepine and Z-drug prescribing were determined. Age (16-44, 45-64, ≥65 years) and gender trends were investigated. Benzodiazepine prescribing rates decreased significantly from 225.92/1000 population (95% CI 224.94-226.89) in 2005 to 166.07/1000 population (95% CI 165.38-166.75) in 2015 (P < 0.0001). Z-drug prescribing rates increased significantly from 95.36/1000 population (95% CI 94.73-96.00) in 2005 to 109.11/1000 population (95% CI 108.56-109.67) in 2015 (P = 0.048). Approximately one-third of individuals dispensed either benzodiazepines or Z-drugs were receiving long-term prescriptions (>90 days). The proportion of those receiving >1 benzodiazepine and/or...Continue Reading

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Citations

Jul 25, 2019·The European Journal of General Practice·Paul KeatingAndrew O'Regan
Sep 15, 2019·Basic & Clinical Pharmacology & Toxicology·Hyunji KooSun-Young Jung
Nov 17, 2019·European Journal of Clinical Pharmacology·Stephanie HeinemannWolfgang Himmel
Jun 16, 2021·Research in Social & Administrative Pharmacy : RSAP·Seán CollFrank Moriarty
Jun 15, 2021·The International Journal of Risk & Safety in Medicine·Giovanni MansuetoFiammetta Cosci
May 6, 2021·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Mumtaz BegumNigel Stocks
Nov 9, 2021·Pharmacoepidemiology and Drug Safety·Emmanuelle GosselinCaroline Sirois
Dec 5, 2021·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Tom LynchCathal A Cadogan

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