Benzodiazepine inhibition of adenosine uptake is not prevented by benzodiazepine antagonists

European Journal of Pharmacology
P F MorganT W Stone

Abstract

Uptake of [3H]adenosine into rat cerebral cortex synaptosomes was studied. Hexobendine (10(-5) M) and the benzodiazepine agonists diazepam (10(-5) M) and flurazepam (10(-4) M) significantly inhibited this uptake, but only if the compounds were pre-incubated for 10 min in the case of the benzodiazepines. The benzodiazepine antagonists Ro15-1788 (10(-5) M) and CGS 8216 (10(-5) M) failed to reverse the action of benzodiazepine agonists or hexobendine on [3H]adenosine uptake. The results add weight to the view that inhibition of adenosine uptake processes by benzodiazepines do not contribute to their behavioural effects.

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Jan 1, 1986·Psychopharmacology·S E File, S Pellow
Jan 1, 1991·Psychopharmacology·B SöderpalmJ A Engel
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Jan 1, 1984·Journal of Psychiatric Research·S H Snyder, P Sklar

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